MEOX1
| Mesenchyme homeobox 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MEOX1 ; KFS2; MOX1 | ||||||||||||
| External IDs | OMIM: 600147 MGI: 103220 HomoloGene: 3326 GeneCards: MEOX1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4222 | 17285 | |||||||||||
| Ensembl | ENSG00000005102 | ENSMUSG00000001493 | |||||||||||
| UniProt | P50221 | P32442 | |||||||||||
| RefSeq (mRNA) | NM_001040002 | NM_010791 | |||||||||||
| RefSeq (protein) | NP_001035091 | NP_034921 | |||||||||||
| Location (UCSC) | Chr 17: 41.72 – 41.74 Mb | Chr 11: 101.88 – 101.89 Mb | |||||||||||
| PubMed search | |||||||||||||
Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.[1][2]
Function
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.[2]
Interactions
MEOX1 has been shown to interact with PAX1[3] and PAX3.[3]
References
- ↑ Futreal PA, Cochran C, Rosenthal J, Miki Y, Swenson J, Hobbs M et al. (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet 3 (8): 1359–64. doi:10.1093/hmg/3.8.1359. PMID 7987315.
- ↑ 2.0 2.1 "Entrez Gene: MEOX1 mesenchyme homeobox 1".
- ↑ 3.0 3.1 Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.
Further reading
- Jones KA, Black DM, Brown MA, Griffiths BL, Nicolai HM, Chambers JA et al. (1995). "The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase". Hum. Mol. Genet. 3 (11): 1927–34. doi:10.1093/hmg/3.11.1927. PMID 7874108.
- Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS et al. (1997). "The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin". Differentiation 62 (1): 33–41. doi:10.1046/j.1432-0436.1997.6210033.x. PMID 9373945. Vancouver style error (help)
- Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.
- Petropoulos H, Gianakopoulos PJ, Ridgeway AG, Skerjanc IS (2004). "Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells". J. Biol. Chem. 279 (23): 23874–81. doi:10.1074/jbc.M312612200. PMID 15039437.
- Gianakopoulos PJ, Skerjanc IS (2005). "Hedgehog signaling induces cardiomyogenesis in P19 cells". J. Biol. Chem. 280 (22): 21022–8. doi:10.1074/jbc.M502977200. PMID 15793308.
- Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099. Vancouver style error (help)