MEF2B
MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B), also known as MEF2B, is a human gene.[1]
Interactions
MEF2B has been shown to interact with CABIN1.[2][3]
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[4][5]
See also
References
- ↑ "Entrez Gene: MEF2B MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)".
- ↑ Han, Aidong; Pan Fan; Stroud James C; Youn Hong-Duk; Liu Jun O; Chen Lin (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature (England) 422 (6933): 730–4. doi:10.1038/nature01555. ISSN 0028-0836. PMID 12700764.
- ↑ Youn, H D; Sun L; Prywes R; Liu J O (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science (UNITED STATES) 286 (5440): 790–3. doi:10.1126/science.286.5440.790. ISSN 0036-8075. PMID 10531067.
- ↑ Morin, Ryan D.; Mendez-Lago, Maria; Mungall, Andrew J.; Goya, Rodrigo; Mungall, Karen L.; Corbett, Richard D.; Johnson, Nathalie A.; Severson, Tesa M.; Chiu, Readman; Field, Matthew; Jackman, Shaun; Krzywinski, Martin; Scott, David W.; Trinh, Diane L.; Tamura-Wells, Jessica; Li, Sa; Firme, Marlo R.; Rogic, Sanja; Griffith, Malachi; Chan, Susanna; Yakovenko, Oleksandr; Meyer, Irmtraud M.; Zhao, Eric Y.; Smailus, Duane; Moksa, Michelle; Chittaranjan, Suganthi; Rimsza, Lisa; Brooks-Wilson, Angela; Spinelli, John J.; Ben-Neriah, Susana; Meissner, Barbara; Woolcock, Bruce; Boyle, Merrill; McDonald, Helen; Tam, Angela; Zhao, Yongjun; Delaney, Allen; Zeng, Thomas; Tse, Kane; Butterfield, Yaron; Birol, Inanç; Holt, Rob; Schein, Jacqueline; Horsman, Douglas E.; Moore, Richard; Jones, Steven J. M.; Connors, Joseph M.; Hirst, Martin; Gascoyne, Randy D.; Marra, Marco A. (2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. doi:10.1038/nature10351. ISSN 0028-0836. PMC 3210554. PMID 21796119.
- ↑ Lohr, JG; Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR (Feb 17, 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.
Further reading
- Yu YT, Breitbart RE, Smoot LB (1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.". Genes Dev. 6 (9): 1783–98. doi:10.1101/gad.6.9.1783. PMID 1516833.
- Pollock R, Treisman R (1992). "Human SRF-related proteins: DNA-binding properties and potential regulatory targets.". Genes Dev. 5 (12A): 2327–41. doi:10.1101/gad.5.12a.2327. PMID 1748287.
- Hobson GM, Krahe R, Garcia E (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763.
- Katoh Y, Molkentin JD, Dave V (1998). "MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.". J. Biol. Chem. 273 (3): 1511–8. doi:10.1074/jbc.273.3.1511. PMID 9430690.
- Iida K, Hidaka K, Takeuchi M (1999). "Expression of MEF2 genes during human cardiac development.". Tohoku J. Exp. Med. 187 (1): 15–23. doi:10.1620/tjem.187.15. PMID 10458488.
- Youn HD, Sun L, Prywes R, Liu JO (1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.". Science 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
- Li M, Linseman DA, Allen MP (2001). "Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.". J. Neurosci. 21 (17): 6544–52. PMID 11517243.
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Han A, Pan F, Stroud JC (2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature 422 (6933): 730–4. doi:10.1038/nature01555. PMID 12700764.
- Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Konig S, Hinard V, Arnaudeau S (2004). "Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation". J. Biol. Chem. 279 (27): 28187–96. doi:10.1074/jbc.M313932200. PMID 15084602.
- Gerhard DS, Wagner L, Feingold EA (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Han A, He J, Wu Y (2005). "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2". J. Mol. Biol. 345 (1): 91–102. doi:10.1016/j.jmb.2004.10.033. PMID 15567413.
- Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gong X, Tsai SW, Yan B, Rubin LP (2006). "Cooperation between MEF2 and PPARγ in human intestinal β,β-carotene 15,15'-monooxygenase gene expression". BMC Mol. Biol. 7: 7. doi:10.1186/1471-2199-7-7. PMC 1526748. PMID 16504037.
PDB gallery |
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| | 1egw: CRYSTAL STRUCTURE OF MEF2A CORE BOUND TO DNA |
| 1n6j: Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2 |
| 1tqe: Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 |
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External links
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| | (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
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| | (2.2) Other Cys4 | |
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| | (2.3) Cys2His2 | |
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| | (2.4) Cys6 | |
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| | (2.5) Alternating composition | |
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| | (2.6) WRKY | |
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| | | (0) Other transcription factors |
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| | see also transcription factor/coregulator deficiencies
Index of genetics |
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| | Description |
- Gene expression
- DNA
- replication
- cycle
- recombination
- repair
- binding proteins
- Transcription
- factors
- regulators
- nucleic acids
- RNA
- RNA binding proteins
- ribonucleoproteins
- repeated sequence
- modification
- Translation
- ribosome
- modification
- nexins
- Proteins
- domains
- Structure
- primary
- secondary
- tertiary
- quaternary
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| | Disease |
- Replication and repair
- Transcription factor
- Transcription
- Translation
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