MED28
| Mediator complex subunit 28 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MED28 ; 1500003D12Rik; EG1; magicin | ||||||||||||
| External IDs | OMIM: 610311 MGI: 1914249 HomoloGene: 11873 GeneCards: MED28 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 80306 | 66999 | |||||||||||
| Ensembl | ENSG00000118579 | ENSMUSG00000015804 | |||||||||||
| UniProt | Q9H204 | Q920D3 | |||||||||||
| RefSeq (mRNA) | NM_025205 | NM_025895 | |||||||||||
| RefSeq (protein) | NP_079481 | NP_080171 | |||||||||||
| Location (UCSC) | Chr 4: 17.62 – 17.64 Mb | Chr 5: 45.52 – 45.53 Mb | |||||||||||
| PubMed search | |||||||||||||
| Med28 | |||||||||
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| Identifiers | |||||||||
| Symbol | Med28 | ||||||||
| Pfam | PF11594 | ||||||||
| InterPro | IPR021640 | ||||||||
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Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[1][2][3] It forms part of the Mediator complex.
Interactions
MED28 has been shown to interact with Merlin,[2] Grb2[2] and MED26.[4]
Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[5]
See also
References
- ↑ Liu C, Zhang L, Shao ZM, Beatty P, Sartippour M, Lane TF, Barsky SH, Livingston E, Nguyen M (Jan 2002). "Identification of a novel endothelial-derived gene EG-1". Biochem Biophys Res Commun 290 (1): 602–12. doi:10.1006/bbrc.2001.6119. PMID 11779215.
- ↑ 2.0 2.1 2.2 Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V (Nov 2004). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene 23 (54): 8815–25. doi:10.1038/sj.onc.1208110. PMID 15467741.
- ↑ "Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)".
- ↑ Sato, Shigeo; Tomomori-Sato Chieri, Parmely Tari J, Florens Laurence, Zybailov Boris, Swanson Selene K, Banks Charles A S, Jin Jingji, Cai Yong, Washburn Michael P, Conaway Joan Weliky, Conaway Ronald C (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell (United States) 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. ISSN 1097-2765. PMID 15175163.
- ↑ Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (November 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". J. Biol. Chem. 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.
This article incorporates text from the public domain Pfam and InterPro IPR021640
Further reading
- Suzuki H, Fukunishi Y, Kagawa I et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sato S, Tomomori-Sato C, Banks CA et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
- Tomomori-Sato C, Sato S, Parmely TJ et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Sato S, Tomomori-Sato C, Parmely TJ et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lu M, Zhang L, Maul RS et al. (2005). "The novel gene EG-1 stimulates cellular proliferation". Cancer Res. 65 (14): 6159–66. doi:10.1158/0008-5472.CAN-04-4016. PMID 16024617.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lee MF, Beauchamp RL, Beyer KS et al. (2006). "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation". Biochem. Biophys. Res. Commun. 348 (3): 826–31. doi:10.1016/j.bbrc.2006.07.126. PMID 16899217.
- Lu M, Zhang L, Sartippour MR et al. (2006). "EG-1 interacts with c-Src and activates its signaling pathway". Int. J. Oncol. 29 (4): 1013–8. doi:10.3892/ijo.29.4.1013. PMID 16964398.
- Beyer KS, Beauchamp RL, Lee MF et al. (2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". J. Biol. Chem. 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.