MED24

Mediator complex subunit 24

Identifiers

MED24 ; ARC100; CRSP100; CRSP4; DRIP100; THRAP4; TRAP100

External IDs

OMIM: 607000 MGI: 1344385 HomoloGene: 40795 GeneCards: MED24 Gene

Gene ontology
Molecular function	• RNA polymerase II transcription cofactor activity • transcription cofactor activity • histone acetyltransferase activity • receptor activity • ligand-dependent nuclear receptor transcription coactivator activity • vitamin D receptor binding • thyroid hormone receptor binding
Cellular component	• nucleus • nucleoplasm • mediator complex
Biological process	• regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • gene expression • histone acetylation • stem cell maintenance • intracellular steroid hormone receptor signaling pathway • androgen receptor signaling pathway • positive regulation of transcription, DNA-templated • protein heterooligomerization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
38.18 – 38.22 Mb

Chr 11:
98.7 – 98.73 Mb

PubMed search

Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.^[1]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

Interactions

MED24 has been shown to interact with Estrogen receptor alpha,^[2]^[3] Cyclin-dependent kinase 8,^[3]^[4] Calcitriol receptor^[2]^[4] and BRCA1.^[5]

References

↑ 1.0 1.1 "Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4".
↑ 2.0 2.1 Kitagawa, Hirochika; Fujiki Ryoji, Yoshimura Kimihiro, Mezaki Yoshihiro, Uematsu Yoshikatsu, Matsui Daisuke, Ogawa Satoko, Unno Kiyoe, Okubo Mataichi, Tokita Akifumi, Nakagawa Takeya, Ito Takashi, Ishimi Yukio, Nagasawa Hiromichi, Matsumoto Toshio, Yanagisawa Junn, Kato Shigeaki (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell (United States) 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. ISSN 0092-8674. PMID 12837248.
↑ 3.0 3.1 Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
↑ 4.0 4.1 Ito, M; Yuan C X; Malik S; Gu W; Fondell J D; Yamamura S; Fu Z Y; Zhang X; Qin J; Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638.
↑ Wada, Osamu; Oishi Hajime; Takada Ichiro; Yanagisawa Junn; Yano Tetsu; Kato Shigeaki (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene (England) 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. ISSN 0950-9232. PMID 15208681.

Gustafsson CM, Samuelsson T (2001). "Mediator--a universal complex in transcriptional regulation". Mol. Microbiol. 41 (1): 1–8. doi:10.1046/j.1365-2958.2001.02481.x. PMID 11454195.
Malik S, Roeder RG (2005). "Dynamic regulation of pol II transcription by the mammalian Mediator complex". Trends Biochem. Sci. 30 (5): 256–63. doi:10.1016/j.tibs.2005.03.009. PMID 15896744.
Nagase T; Seki N; Tanaka A et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. doi:10.1073/pnas.93.16.8329. PMC 38670. PMID 8710870.
Rachez C; Suldan Z; Ward J et al. (1998). "A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system". Genes Dev. 12 (12): 1787–800. doi:10.1101/gad.12.12.1787. PMC 316901. PMID 9637681.
Yuan CX; Ito M; Fondell JD et al. (1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7939–44. doi:10.1073/pnas.95.14.7939. PMC 20908. PMID 9653119.
Gu W; Malik S; Ito M et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
Ito M; Yuan CX; Malik S et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
Rachez C; Lemon BD; Suldan Z et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
Näär AM; Beaurang PA; Zhou S et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137–42. doi:10.1073/pnas.96.13.7137. PMC 22029. PMID 10377381.
Zhang J, Fondell JD (1999). "Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors". Mol. Endocrinol. 13 (7): 1130–40. doi:10.1210/me.13.7.1130. PMID 10406464.
Taatjes DJ; Näär AM; Andel F et al. (2002). "Structure, function, and activator-induced conformations of the CRSP coactivator". Science 295 (5557): 1058–62. doi:10.1126/science.1065249. PMID 11834832.
Surapureddi S; Yu S; Bu H et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sato S; Tomomori-Sato C; Banks CA et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Tomomori-Sato C; Sato S; Parmely TJ et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

MED24

Interactions

References

Further reading