MAST2
| Microtubule associated serine/threonine kinase 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MAST2 ; MAST205; MTSSK | ||||||||||||
| External IDs | OMIM: 612257 MGI: 894676 HomoloGene: 7428 IUPHAR: 1511 GeneCards: MAST2 Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 23139 | 17776 | |||||||||||
| Ensembl | ENSG00000086015 | ENSMUSG00000003810 | |||||||||||
| UniProt | Q6P0Q8 | Q60592 | |||||||||||
| RefSeq (mRNA) | NM_015112 | NM_001042743 | |||||||||||
| RefSeq (protein) | NP_055927 | NP_001036208 | |||||||||||
| Location (UCSC) | Chr 1: 46.25 – 46.5 Mb | Chr 4: 116.31 – 116.46 Mb | |||||||||||
| PubMed search | |||||||||||||
Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.[1] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.[2]
Interactions
MAST2 has been shown to interact with PCLKC.[3]
References
- ↑ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2".
- ↑ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666.
- ↑ Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
Further reading
- Walden PD, Cowan NJ (1993). "A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette". Mol. Cell. Biol. 13 (12): 7625–35. PMC 364834. PMID 8246979.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Walden PD, Millette CF (1996). "Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis". Biol. Reprod. 55 (5): 1039–44. doi:10.1095/biolreprod55.5.1039. PMID 8902215.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A et al. (1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Lumeng C, Phelps S, Crawford GE, Walden PD, Barald K, Chamberlain JS (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci. 2 (7): 611–7. doi:10.1038/10165. PMID 10404183.
- Adey NB, Huang L, Ormonde PA, Baumgard ML, Pero R, Byreddy DV et al. (2000). "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding". Cancer Res. 60 (1): 35–7. PMID 10646847.
- Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins". J. Biol. Chem. 276 (12): 9206–13. doi:10.1074/jbc.M008745200. PMID 11099500.
- Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
- Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
- Zhou H, Xiong H, Li H, Plevy SE, Walden PD, Sassaroli M et al. (2004). "Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation". J. Immunol. 172 (4): 2559–68. doi:10.4049/jimmunol.172.4.2559. PMID 14764729.
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200. PMID 15308666.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.