MASP1 (protein)
Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene.[1][2][3]
MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2b, a C3-convertase.[4]
Function
MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.[3]
See also
References
- ↑ Takada F, Takayama Y, Hatsuse H, Kawakami M (October 1993). "A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum". Biochem. Biophys. Res. Commun. 196 (2): 1003–9. doi:10.1006/bbrc.1993.2349. PMID 8240317.
- ↑ Sato T, Endo Y, Matsushita M, Fujita T (April 1994). "Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein". Int. Immunol. 6 (4): 665–9. doi:10.1093/intimm/6.4.665. PMID 8018603.
- ↑ 3.0 3.1 "Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)".
- ↑ Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T (1 September 2000). "Proteolytic activities of two types of mannose-binding lectin-associated serine protease". J. Immunol. 165 (5): 2637–42. doi:10.4049/jimmunol.165.5.2637. PMID 10946292.
Further reading
- Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N (2010). "Genetic susceptibility to distinct bladder cancer subphenotypes.". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.
- Petersen SV, Thiel S, Jensenius JC (2001). "The mannan-binding lectin pathway of complement activation: biology and disease association.". Mol. Immunol. 38 (2-3): 133–49. doi:10.1016/S0161-5890(01)00038-4. PMID 11532276.
- Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ (2009). "Common variation in genes related to innate immunity and risk of adult glioma.". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. doi:10.1158/1055-9965.EPI-08-1041. PMC 2771723. PMID 19423540.
- Dobó J, Harmat V, Beinrohr L, Sebestyén E, Závodszky P, Gál P (2009). "MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity.". J. Immunol. 183 (2): 1207–14. doi:10.4049/jimmunol.0901141. PMID 19564340.
- Skjoedt MO, Hummelshoj T, Palarasah Y, Honore C, Koch C, Skjodt K, Garred P (2010). "A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation.". J. Biol. Chem. 285 (11): 8234–43. doi:10.1074/jbc.M109.065805. PMC 2832975. PMID 20053996.
- Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia.". Hum. Immunol. 71 (7): 727–30. doi:10.1016/j.humimm.2010.04.004. PMC 2967770. PMID 20438785.
- Kocsis A, Kékesi KA, Szász R, Végh BM, Balczer J, Dobó J, Závodszky P, Gál P, Pál G (2010). "Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.". J. Immunol. 185 (7): 4169–78. doi:10.4049/jimmunol.1001819. PMID 20817870.
- Rooryck C, Diaz-Font A, Osborn DP, Chabchoub E, Hernandez-Hernandez V, Shamseldin H, Kenny J, Waters A, Jenkins D, Kaissi AA, Leal GF, Dallapiccola B, Carnevale F, Bitner-Glindzicz M, Lees M, Hennekam R, Stanier P, Burns AJ, Peeters H, Alkuraya FS, Beales PL (2011). "Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome.". Nat. Genet. 43 (3): 197–203. doi:10.1038/ng.757. PMC 3045628. PMID 21258343.
- Megyeri M, Makó V, Beinrohr L, Doleschall Z, Prohászka Z, Cervenak L, Závodszky P, Gál P (2009). "Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function.". J. Immunol. 183 (5): 3409–16. doi:10.4049/jimmunol.0900879. PMID 19667088.
- Sirmaci A, Walsh T, Akay H, Spiliopoulos M, Sakalar YB, Hasanefendioğlu-Bayrak A, Duman D, Farooq A, King MC, Tekin M (2010). "MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes.". Am. J. Hum. Genet. 87 (5): 679–86. doi:10.1016/j.ajhg.2010.09.018. PMC 2978960. PMID 21035106.
- Hosgood HD, Menashe I, He X, Chanock S, Lan Q (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease.". Respir Med 103 (12): 1866–70. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
- Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.". Carcinogenesis 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
- Kang JU, Koo SH, Kwon KC, Park JW, Kim JM (2009). "Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2-q29 in squamous cell carcinoma of the lung.". BMC Cancer 9: 237. doi:10.1186/1471-2407-9-237. PMC 2716371. PMID 19607727.
- Skjoedt MO, Palarasah Y, Munthe-Fog L, Jie Ma Y, Weiss G, Skjodt K, Koch C, Garred P (2010). "MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation.". Immunobiology 215 (11): 921–31. doi:10.1016/j.imbio.2009.10.006. PMID 19939495.
- Degn SE, Hansen AG, Steffensen R, Jacobsen C, Jensenius JC, Thiel S (2009). "MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation.". J. Immunol. 183 (11): 7371–8. doi:10.4049/jimmunol.0902388. PMID 19917686.
- Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD (2010). "Risk of meningioma and common variation in genes related to innate immunity.". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. doi:10.1158/1055-9965.EPI-09-1151. PMC 3169167. PMID 20406964.
- Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, Jones S, Collins A, Stone E, Lotery A (2008). "Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.". Lancet 372 (9652): 1828–34. doi:10.1016/S0140-6736(08)61348-3. PMID 18842294.
- Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q (2009). "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.". Environ. Mol. Mutagen. 50 (4): 285–90. doi:10.1002/em.20452. PMC 2666781. PMID 19170196.
- Duus K, Thielens NM, Lacroix M, Tacnet P, Frachet P, Holmskov U, Houen G (2010). "CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.". FEBS J. 277 (23): 4956–64. doi:10.1111/j.1742-4658.2010.07901.x. PMID 21054788.
- Degn SE, Jensen L, Gál P, Dobó J, Holmvad SH, Jensenius JC, Thiel S (2010). "Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system.". J. Immunol. Methods 361 (1-2): 37–50. doi:10.1016/j.jim.2010.07.006. PMID 20673767.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| | Inhibitors | |
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| | Complement receptors | |
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| | Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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| | Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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| | Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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