MARK3
| MAP/microtubule affinity-regulating kinase 3 | |||||||||||||
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 PDB rendering based on 1ul7. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MARK3 ; CTAK1; KP78; PAR1A; Par-1a | ||||||||||||
| External IDs | OMIM: 602678 MGI: 1341865 HomoloGene: 55653 IUPHAR: 2099 ChEMBL: 5600 GeneCards: MARK3 Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4140 | 17169 | |||||||||||
| Ensembl | ENSG00000075413 | ENSMUSG00000007411 | |||||||||||
| UniProt | P27448 | Q03141 | |||||||||||
| RefSeq (mRNA) | NM_001128918 | NM_021516 | |||||||||||
| RefSeq (protein) | NP_001122390 | NP_067491 | |||||||||||
| Location (UCSC) | Chr 14: 103.85 – 103.97 Mb | Chr 12: 111.57 – 111.66 Mb | |||||||||||
| PubMed search | |||||||||||||
MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.[1][2]
Interactions
MARK3 has been shown to interact with Stratifin.[3][4]
References
- ↑ Ono T, Kawabe T, Sonta S, Okamoto T (April 1998). "Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization". Cytogenet Cell Genet 79 (1-2): 101–2. doi:10.1159/000134692. PMID 9533022.
- ↑ "Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3".
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Further reading
- Tassan JP, Le Goff X (2004). "An overview of the KIN1/PAR-1/MARK kinase family.". Biol. Cell 96 (3): 193–9. doi:10.1016/j.biolcel.2003.10.009. PMID 15182702.
- Meller N, Liu YC, Collins TL, Bonnefoy-Bérard N, Baier G, Isakov N et al. (1996). "Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.". Mol. Cell. Biol. 16 (10): 5782–91. PMC 231579. PMID 8816492.
- Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z et al. (1998). "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.". Cell Growth Differ. 9 (3): 197–208. PMID 9543386.
- Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ et al. (2001). "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.". Nat. Cell Biol. 3 (7): 628–36. doi:10.1038/35083016. PMID 11433294.
- Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D (2003). "Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.". Oncogene 22 (30): 4752–6. doi:10.1038/sj.onc.1206669. PMID 12879020.
- Müller J, Ritt DA, Copeland TD, Morrison DK (2003). "Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.". EMBO J. 22 (17): 4431–42. doi:10.1093/emboj/cdg426. PMC 202368. PMID 12941695.
- Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
- Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
- Bachmann M, Hennemann H, Xing PX, Hoffmann I, Möröy T (2005). "The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint.". J. Biol. Chem. 279 (46): 48319–28. doi:10.1074/jbc.M404440200. PMID 15319445.
- Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR (2007). "Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.". J. Cell. Sci. 119 (Pt 19): 4059–70. doi:10.1242/jcs.03097. PMID 16968750.
- Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N et al. (2006). "New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.". Mol. Cell. Biol. 26 (19): 7086–102. doi:10.1128/MCB.00231-06. PMC 1592903. PMID 16980613.
- Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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