MARK1

MAP/microtubule affinity-regulating kinase 1

PDB rendering based on 2hak.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsMARK1 ; MARK; Par-1c; Par1c
External IDsOMIM: 606511 MGI: 2664902 HomoloGene: 49552 IUPHAR: 2097 ChEMBL: 5940 GeneCards: MARK1 Gene
EC number2.7.11.1, 2.7.11.26
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez4139226778
EnsemblENSG00000116141ENSMUSG00000026620
UniProtQ9P0L2Q8VHJ5
RefSeq (mRNA)NM_001286124NM_145515
RefSeq (protein)NP_001273053NP_663490
Location (UCSC)Chr 1:
220.7 – 220.84 Mb		Chr 1:
184.9 – 185 Mb
PubMed search

Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the MARK1 gene.[1][2]

References

  1. ↑ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (May 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
  2. ↑ "Entrez Gene: MARK1 MAP/microtubule affinity-regulating kinase 1".

Further reading

  • Drewes G, Trinczek B, Illenberger S et al. (1995). "Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.". J. Biol. Chem. 270 (13): 7679–88. doi:10.1074/jbc.270.13.7679. PMID 7706316.
  • Yang SD, Yu JS, Shiah SG, Huang JJ (1994). "Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.". J. Neurochem. 63 (4): 1416–25. doi:10.1046/j.1471-4159.1994.63041416.x. PMID 7931292.
  • Illenberger S, Drewes G, Trinczek B et al. (1996). "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.". J. Biol. Chem. 271 (18): 10834–43. doi:10.1074/jbc.271.18.10834. PMID 8631898.
  • Paudel HK (1997). "The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.". J. Biol. Chem. 272 (3): 1777–85. doi:10.1074/jbc.272.3.1777. PMID 8999860.
  • Sengupta A, Kabat J, Novak M et al. (1998). "Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.". Arch. Biochem. Biophys. 357 (2): 299–309. doi:10.1006/abbi.1998.0813. PMID 9735171.
  • Wang JZ, Wu Q, Smith A et al. (1998). "Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.". FEBS Lett. 436 (1): 28–34. doi:10.1016/S0014-5793(98)01090-4. PMID 9771888.
  • Hanger DP, Betts JC, Loviny TL et al. (1998). "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.". J. Neurochem. 71 (6): 2465–76. doi:10.1046/j.1471-4159.1998.71062465.x. PMID 9832145.
  • Schneider A, Biernat J, von Bergen M et al. (1999). "Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.". Biochemistry 38 (12): 3549–58. doi:10.1021/bi981874p. PMID 10090741.
  • Reynolds CH, Betts JC, Blackstock WP et al. (2000). "Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.". J. Neurochem. 74 (4): 1587–95. doi:10.1046/j.1471-4159.2000.0741587.x. PMID 10737616.
  • Nagase T, Kikuno R, Ishikawa K et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  • Liu F, Iqbal K, Grundke-Iqbal I, Gong CX (2002). "Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.". FEBS Lett. 530 (1–3): 209–14. doi:10.1016/S0014-5793(02)03487-7. PMID 12387894.
  • Liu F, Zaidi T, Iqbal K et al. (2003). "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5". Neuroscience 115 (3): 829–37. doi:10.1016/S0306-4522(02)00510-9. PMID 12435421.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Timm T, Li XY, Biernat J et al. (2003). "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1". EMBO J. 22 (19): 5090–101. doi:10.1093/emboj/cdg447. PMC 204455. PMID 14517247.
  • Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lizcano JM, Göransson O, Toth R et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Benzinger A, Muster N, Koch HB et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.