MAP kinase kinase kinase
| Mitogen-activated protein kinase kinase kinase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.11.25 | ||||||||
| CAS number | 146702-84-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.
In humans there are at least 19 genes:
- MAP3K1 (aka MEKK1)
- MAP3K2
- MAP3K3 (aka MEKK3)
- MAP3K4
- MAP3K5 (aka ASK1)
- MAP3K6 (aka ASK2)
- MAP3K7 (aka MEKK7) (aka TAK1)
- MAP3K8 (aka TPL2 or Tpl2)
- MAP3K9
- MAP3K10
- MAP3K11 (aka MEKK11) (aka MLK3)
- MAP3K12 (aka MUK)
- MAP3K13 (aka LZK)
- MAP3K14
- MAP3K15
- MAP3K16 (aka TAO1 or TAOK1)
- MAP3K17 (aka TAO2 or TAOK2)
- RAF1
- BRAF
- ARAF
- ZAK (aka MLTK)
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).
MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1]
MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2]
MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]
Additional Images
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MAPK pathway. Many of the MAP3K's here are labelled by their alternative names.
See also
- Signal transduction
- MAP kinase
- MAP kinase kinase
- MAP kinase kinase kinase kinase
External links
- MAP Kinase Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.7.11.25
References
- ↑ Yan M et al. (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature 372 (6508): 798–800. doi:10.1038/372798a0. PMID 7997270.
- ↑ Ellinger-Ziegelbauer H et al. (1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". J Biol Chem. 272 (5): 2668–2674. doi:10.1074/jbc.272.5.2668. PMID 9006902.
- ↑ Yamaguchi K et al. (1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science 270 (5244): 2008–2011. doi:10.1126/science.270.5244.2008. PMID 8533096.
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