MAPK6
| Mitogen-activated protein kinase 6 | |||||||||||||
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 PDB rendering based on 2i6l. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MAPK6 ; ERK3; HsT17250; PRKM6; p97MAPK | ||||||||||||
| External IDs | OMIM: 602904 MGI: 1354946 HomoloGene: 55683 IUPHAR: 2092 ChEMBL: 5121 GeneCards: MAPK6 Gene | ||||||||||||
| EC number | 2.7.11.24 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5597 | 50772 | |||||||||||
| Ensembl | ENSG00000069956 | ENSMUSG00000042688 | |||||||||||
| UniProt | Q16659 | Q61532 | |||||||||||
| RefSeq (mRNA) | NM_002748 | NM_015806 | |||||||||||
| RefSeq (protein) | NP_002739 | NP_056621 | |||||||||||
| Location (UCSC) | Chr 15: 52.24 – 52.36 Mb | Chr 9: 75.37 – 75.41 Mb | |||||||||||
| PubMed search | |||||||||||||
Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.[1][2]
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.[2]
References
- ↑ Meloche S, Beatty BG, Pellerin J (Dec 1996). "Primary structure, expression and chromosomal locus of a human homolog of rat ERK3". Oncogene 13 (7): 1575–9. PMID 8875998.
- ↑ 2.0 2.1 "Entrez Gene: MAPK6 mitogen-activated protein kinase 6".
External links
Further reading
- Boulton TG; Nye SH; Robbins DJ et al. (1991). "ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF". Cell 65 (4): 663–675. doi:10.1016/0092-8674(91)90098-J. PMID 2032290.
- Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMC 359359. PMID 7969157.
- Cheng M, Boulton TG, Cobb MH (1996). "ERK3 is a constitutively nuclear protein kinase". J. Biol. Chem. 271 (15): 8951–8958. doi:10.1074/jbc.271.15.8951. PMID 8621539.
- Sauma S, Friedman E (1996). "Increased expression of protein kinase C beta activates ERK3". J. Biol. Chem. 271 (19): 11422–11426. doi:10.1074/jbc.271.19.11422. PMID 8626698.
- Zimmermann J, Lamerant N, Grossenbacher R, Furst P (2001). "Proteasome- and p38-dependent regulation of ERK3 expression". J. Biol. Chem. 276 (14): 10759–10766. doi:10.1074/jbc.M008567200. PMID 11148204.
- Robinson MJ, Xu Be BE, Stippec S, Cobb MH (2002). "Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo". J. Biol. Chem. 277 (7): 5094–5100. doi:10.1074/jbc.M110935200. PMID 11741894.
- Kinet S; Bernard F; Mongellaz C et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood 100 (7): 2546–2553. doi:10.1182/blood-2002-03-0819. PMID 12239168.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Coulombe P; Rodier G; Pelletier S et al. (2003). "Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation". Mol. Cell. Biol. 23 (13): 4542–4558. doi:10.1128/MCB.23.13.4542-4558.2003. PMC 164847. PMID 12808096.
- Julien C, Coulombe P, Meloche S (2004). "Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression". J. Biol. Chem. 278 (43): 42615–42624. doi:10.1074/jbc.M302724200. PMID 12915405.
- Rai R, Mahale A, Saranath D (2004). "Molecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma". Oral Oncol. 40 (7): 705–712. doi:10.1016/j.oraloncology.2004.01.010. PMID 15172640.
- Coulombe P; Rodier G; Bonneil E et al. (2004). "N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome". Mol. Cell. Biol. 24 (14): 6140–6150. doi:10.1128/MCB.24.14.6140-6150.2004. PMC 434260. PMID 15226418.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
- Hoeflich KP; Eby MT; Forrest WF et al. (2006). "Regulation of ERK3/MAPK6 expression by BRAF". Int. J. Oncol. 29 (4): 839–49. doi:10.3892/ijo.29.4.839. PMID 16964379.
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