MAPK4
| Mitogen-activated protein kinase 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MAPK4 ; ERK-4; ERK4; PRKM4; p63-MAPK; p63MAPK | ||||||||||||
| External IDs | OMIM: 176949 MGI: 2444559 HomoloGene: 2058 IUPHAR: 2091 ChEMBL: 5759 GeneCards: MAPK4 Gene | ||||||||||||
| EC number | 2.7.11.24 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5596 | 225724 | |||||||||||
| Ensembl | ENSG00000141639 | ENSMUSG00000024558 | |||||||||||
| UniProt | P31152 | Q6P5G0 | |||||||||||
| RefSeq (mRNA) | NM_001292039 | NM_172632 | |||||||||||
| RefSeq (protein) | NP_001278968 | NP_766220 | |||||||||||
| Location (UCSC) | Chr 18: 48.09 – 48.26 Mb | Chr 18: 73.93 – 74.07 Mb | |||||||||||
| PubMed search | |||||||||||||
Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[1][2]
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[2]
The Arabidopsis MAPK4 is important in signalling [3]
References
- ↑ Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene 9 (2): 647–9. PMID 8290275.
- ↑ 2.0 2.1 "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
- ↑ Petersen, M. Brodersen, P. Naested, H. Andreasson, E. Lindhart, U. Johansen, B. Nielsen, M. B. Lacy, M., Austin, M. J. Parker, J. E. Sharma, S. B. Klessig, D. F.. Martienssen, R. Mattsson, O. Jensen, A. B. and Mundy, J. Arabidopsis MAP kinase 4 negatively regulates systemic acquired resistance. (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell 103 (7): 1111–1120. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186.
External links
Further reading
- Seger R, Krebs EG (1995). "The MAPK signaling cascade". FASEB J. 9 (9): 726–35. PMID 7601337.
- Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
- Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways". Curr. Opin. Cell Biol. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID 9069255.
- Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Lett. 304 (2–3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID 1319925.
- Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMC 359359. PMID 7969157.
- Kinet S, Bernard F, Mongellaz C et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sun M, Wei Y, Yao L et al. (2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochem. Biophys. Res. Commun. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641.
- Kant S, Schumacher S, Singh MK et al. (2007). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". J. Biol. Chem. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613.