MAPK15

Mitogen-activated protein kinase 15

Identifiers

MAPK15 ; ERK7; ERK8

External IDs

MGI: 2652894 HomoloGene: 16371 IUPHAR: 2090 ChEMBL: 5198 GeneCards: MAPK15 Gene

Gene ontology
Molecular function	• MAP kinase activity • ATP binding • SH3 domain binding
Cellular component	• extracellular region • intracellular • nucleus
Biological process	• negative regulation of transcription from RNA polymerase II promoter • MAPK cascade • positive regulation of protein phosphorylation • negative regulation of DNA replication • positive regulation of protein ubiquitination • response to estradiol • positive regulation of protein catabolic process • protein autophosphorylation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000181085

ENSMUSG00000063704

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
144.8 – 144.8 Mb

Chr 15:
75.99 – 76 Mb

PubMed search

Mitogen-activated protein kinase 15 is an enzyme that in humans is encoded by the MAPK15 gene.^[1]^[2]

References

↑ Abe MK, Saelzler MP, Espinosa R 3rd, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR (May 2002). "ERK8, a new member of the mitogen-activated protein kinase family". J Biol Chem 277 (19): 16733–43. doi:10.1074/jbc.M112483200. PMID 11875070.
↑ "Entrez Gene: MAPK15 mitogen-activated protein kinase 15".

External links

MAP Kinase Resource .

Further reading

Saelzler MP, Spackman CC, Liu Y et al. (2006). "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.". J. Biol. Chem. 281 (24): 16821–32. doi:10.1074/jbc.M512418200. PMID 16624805.
Iavarone C, Acunzo M, Carlomagno F et al. (2006). "Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.". J. Biol. Chem. 281 (15): 10567–76. doi:10.1074/jbc.M513397200. PMID 16484222.
Klevernic IV, Stafford MJ, Morrice N et al. (2006). "Characterization of the reversible phosphorylation and activation of ERK8.". Biochem. J. 394 (Pt 1): 365–73. doi:10.1042/BJ20051288. PMC 1386035. PMID 16336213.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kinet S, Bernard F, Mongellaz C et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.". Blood 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
Qian Z, Okuhara D, Abe MK, Rosner MR (1999). "Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.". J. Biol. Chem. 274 (3): 1621–7. doi:10.1074/jbc.274.3.1621. PMID 9880541.