MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1

Identifiers

External IDs

OMIM: 601983 MGI: 1346882 HomoloGene: 5199 IUPHAR: 2085 ChEMBL: 5749 GeneCards: MAP4K1 Gene

2.7.11.1

Gene ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • small GTPase regulator activity • protein binding • ATP binding • MAP kinase kinase kinase kinase activity
Cellular component	• membrane
Biological process	• activation of MAPKKK activity • protein phosphorylation • response to stress • activation of JUN kinase activity • cell proliferation • peptidyl-serine phosphorylation • intracellular signal transduction • protein autophosphorylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
39.08 – 39.11 Mb

Chr 7:
28.98 – 29 Mb

PubMed search

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.^[1] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).

Interactions

MAP4K1 has been shown to interact with:

References

↑ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
↑ Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R et al. (Aug 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. doi:10.1084/jem.194.4.529. PMC 2193495. PMID 11514608.
↑ 3.0 3.1 3.2 Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS et al. (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
↑ 4.0 4.1 4.2 4.3 Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM et al. (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. PMC 116064. PMID 9891069.
↑ 5.0 5.1 5.2 5.3 5.4 Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR et al. (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
↑ Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC et al. (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
↑ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH et al. (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
↑ 8.0 8.1 Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. PMID 9346925.