MAP3K9

Mitogen-activated protein kinase kinase kinase 9

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3DTC

Identifiers

MAP3K9 ; MEKK9; MLK1; PRKE1

External IDs

OMIM: 600136 MGI: 2449952 HomoloGene: 76377 IUPHAR: 2084 ChEMBL: 2872 GeneCards: MAP3K9 Gene

Gene ontology
Molecular function	• protein serine/threonine kinase activity • JUN kinase kinase kinase activity • MAP kinase kinase activity • protein tyrosine kinase activity • protein binding • ATP binding • protein homodimerization activity
Cellular component	• cellular_component
Biological process	• transcription, DNA-templated • regulation of transcription, DNA-templated • protein phosphorylation • apoptotic process • activation of JNKK activity • activation of JUN kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of apoptotic process • protein autophosphorylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000006432

ENSMUSG00000042724

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
71.19 – 71.28 Mb

Chr 12:
81.71 – 81.78 Mb

PubMed search

Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene.^[1]

References

↑ "Entrez Gene: MAP3K9 mitogen-activated protein kinase kinase kinase 9".

Further reading

Gallo KA, Mark MR, Scadden DT et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.
Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.". Eur. J. Biochem. 213 (2): 701–10. doi:10.1111/j.1432-1033.1993.tb17810.x. PMID 8477742.
Dorow DS, Devereux L, Tu GF et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.". Eur. J. Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
Xu Z, Maroney AC, Dobrzanski P et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.". Mol. Cell. Biol. 21 (14): 4713–24. doi:10.1128/MCB.21.14.4713-4724.2001. PMC 87148. PMID 11416147.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Durkin JT, Holskin BP, Kopec KK et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.". Biochemistry 43 (51): 16348–55. doi:10.1021/bi049866y. PMID 15610029.