MAP3K7IP3

TGF-beta activated kinase 1/MAP3K7 binding protein 3
Identifiers
SymbolsTAB3 ; MAP3K7IP3; NAP1
External IDsOMIM: 300480 MGI: 1913974 HomoloGene: 17673 GeneCards: TAB3 Gene
Orthologs
SpeciesHumanMouse
Entrez25739766724
EnsemblENSG00000157625ENSMUSG00000035476
UniProtQ8N5C8Q571K4
RefSeq (mRNA)NM_152787NM_025729
RefSeq (protein)NP_690000NP_080005
Location (UCSC)Chr X:
30.85 – 30.99 Mb
Chr X:
85.57 – 85.63 Mb
PubMed search

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[1][2][3]

Function

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

Interactions

MAP3K7IP3 has been shown to interact with MAP3K7IP2,[1] MAP3K7IP1[2] and MAP3K7.[1][2]

References

  1. 1.0 1.1 1.2 Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Nov 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
  2. 2.0 2.1 2.2 Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem J 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
  3. 3.0 3.1 "Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3".

Further reading