MAP3K7IP3
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[1][2][3]
Function
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
Interactions
MAP3K7IP3 has been shown to interact with MAP3K7IP2,[1] MAP3K7IP1[2] and MAP3K7.[1][2]
References
- ↑ 1.0 1.1 1.2 Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Nov 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
- ↑ 2.0 2.1 2.2 Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem J 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
- ↑ 3.0 3.1 "Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3".
Further reading
- Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z et al. (2004). "Identification of a human NF-kappaB-activating protein, TAB3.". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2028–33. doi:10.1073/pnas.0307314101. PMC 357046. PMID 14766965.
- Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A et al. (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.". Mol. Cell 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC et al. (2007). "TAK1-dependent signaling requires functional interaction with TAB2/TAB3.". J. Biol. Chem. 282 (6): 3918–28. doi:10.1074/jbc.M608867200. PMC 3197015. PMID 17158449.