MAP2K6

Mitogen-activated protein kinase kinase 6
Rendering based on PDB 3ENM.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Y8O, 3ENM, 3FME, 3VN9
Identifiers
Symbols	MAP2K6 ; MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3
External IDs	OMIM: 601254 MGI: 1346870 HomoloGene: 55686 IUPHAR: 2067 ChEMBL: 2171 GeneCards: MAP2K6 Gene
EC number	2.7.12.2
Gene ontology Molecular function • protein serine/threonine kinase activity • MAP kinase kinase activity • protein tyrosine kinase activity • protein binding • ATP binding • protein kinase binding Cellular component • nucleoplasm • cytosol • cytoskeleton Biological process • activation of MAPK activity • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • response to ischemia • transcription, DNA-templated • regulation of transcription, DNA-templated • apoptotic process • DNA damage induced protein phosphorylation • cell cycle arrest • signal transduction • peptidyl-tyrosine phosphorylation • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • response to drug • muscle cell differentiation • positive regulation of apoptotic process • innate immune response • positive regulation of muscle cell differentiation • stress-activated MAPK cascade • cardiac muscle contraction • nucleotide-binding oligomerization domain containing signaling pathway • cellular response to sorbitol Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5608	26399
Ensembl	ENSG00000108984	ENSMUSG00000020623
UniProt	P52564	P70236
RefSeq (mRNA)	NM_002758	NM_011943
RefSeq (protein)	NP_002749	NP_036073
Location (UCSC)	Chr 17: 67.41 – 67.54 Mb	Chr 11: 110.4 – 110.53 Mb
PubMed search

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.^[1]

Function

MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.^[2]

Interactions

MAP2K6 has been shown to interact with TAOK2,^[3] ASK1,^[4][5] MAPK14^[3][6][7][8] and MAP3K7.^{[9][10][11][12]}

References

Further reading