MAP2K1

Mitogen-activated protein kinase kinase 1
PDB rendering based on 1s9j.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1S9J, 2P55, 3DV3, 3DY7, 3E8N, 3EQB, 3EQC, 3EQD, 3EQF, 3EQG, 3EQH, 3EQI, 3MBL, 3ORN, 3OS3, 3PP1, 3SLS, 3V01, 3V04, 3VVH, 3W8Q, 3ZLS, 3ZLW, 3ZLX, 3ZLY, 3ZM4, 4AN2, 4AN3, 4AN9, 4ANB, 4ARK, 4LMN
Identifiers
Symbols	MAP2K1 ; CFC3; MAPKK1; MEK1; MKK1; PRKMK1
External IDs	OMIM: 176872 MGI: 1346866 HomoloGene: 2063 IUPHAR: 2062 ChEMBL: 3587 GeneCards: MAP2K1 Gene
EC number	2.7.12.2
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • MAP kinase kinase activity • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • receptor signaling protein tyrosine phosphatase activity • protein binding • ATP binding • Ras GTPase binding • mitogen-activated protein kinase kinase kinase binding • protein serine/threonine kinase activator activity Cellular component • nucleus • cytoplasm • mitochondrion • early endosome • late endosome • Golgi apparatus • microtubule organizing center • cytosol • plasma membrane • focal adhesion • cell cortex • dendrite cytoplasm • perikaryon • perinuclear region of cytoplasm • extracellular vesicular exosome Biological process • MAPK cascade • activation of MAPKK activity • activation of MAPK activity • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • regulation of vascular smooth muscle contraction • cellular component movement • chemotaxis • response to oxidative stress • cell cycle arrest • mitotic nuclear division • signal transduction • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • Ras protein signal transduction • axon guidance • cell proliferation • negative regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • positive regulation of gene expression • peptidyl-tyrosine phosphorylation • keratinocyte differentiation • positive regulation of cell migration • positive regulation of Ras GTPase activity • melanosome transport • regulation of stress-activated MAPK cascade • positive regulation of transcription elongation from RNA polymerase II promoter • negative regulation of homotypic cell-cell adhesion • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • innate immune response • positive regulation of cell differentiation • positive regulation of Ras protein signal transduction • vesicle transport along microtubule • neurotrophin TRK receptor signaling pathway • Golgi inheritance • response to axon injury • cell motility • protein heterooligomerization • response to glucocorticoid • stress-activated MAPK cascade • placenta blood vessel development • labyrinthine layer development • positive regulation of protein serine/threonine kinase activity • regulation of Golgi inheritance • cellular senescence • regulation of early endosome to late endosome transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5604	26395
Ensembl	ENSG00000169032	ENSMUSG00000004936
UniProt	Q02750	P31938
RefSeq (mRNA)	NM_002755	NM_008927
RefSeq (protein)	NP_002746	NP_032953
Location (UCSC)	Chr 15: 66.68 – 66.78 Mb	Chr 9: 64.19 – 64.25 Mb
PubMed search

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.^[1][2]

Function

The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.^[3]

Interactions

MAP2K1 has been shown to interact with C-Raf,^[4] Phosphatidylethanolamine binding protein 1,^[4] MAP2K1IP1,^[5][6] GRB10,^[7] MAPK3,^{[6][8][9][10][11]} MAPK8IP3,^[12][13] MAPK1^{[4][5][14][15][16][17]} MP1,^[6] and MAP3K1.^[18]

References

Further reading

External links

• GeneReviews/NCBI/NIH/UW entry on Noonan syndrome
• GeneReviews/NCBI/NIH/UW entry on Cardiofaciocutaneous Syndrome

PDB gallery 1s9j: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP