MALT1

Mucosa associated lymphoid tissue lymphoma translocation gene 1
PDB rendering based on 2g7r.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2G7R, 3BFO, 3K0W, 3UO8, 3UOA, 3V4O, 3V55, 4I1R
Identifiers
Symbols	MALT1 ; IMD12; MLT; MLT1
External IDs	OMIM: 604860 MGI: 2445027 HomoloGene: 4938 GeneCards: MALT1 Gene
EC number	3.4.22.-
Gene ontology Molecular function • protease binding • cysteine-type endopeptidase activity • ubiquitin-protein transferase activity • signal transducer activity • protein binding • peptidase activity • kinase activator activity • protein self-association Cellular component • nucleus • nucleolus • cytoplasm • cytosol • plasma membrane • CBM complex • protein complex • perinuclear region of cytoplasm Biological process • B-1 B cell differentiation • response to molecule of bacterial origin • positive regulation of T cell cytokine production • proteolysis • defense response • activation of NF-kappaB-inducing kinase activity • response to fungus • protein ubiquitination • positive regulation of protein ubiquitination • positive regulation of interleukin-2 production • Fc-epsilon receptor signaling pathway • T cell proliferation • regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • T cell receptor signaling pathway • regulation of T cell receptor signaling pathway • positive regulation of T cell activation • positive regulation of NF-kappaB transcription factor activity • nuclear export • protein oligomerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10892	240354
Ensembl	ENSG00000172175	ENSMUSG00000032688
UniProt	Q9UDY8	Q2TBA3
RefSeq (mRNA)	NM_006785	NM_172833
RefSeq (protein)	NP_006776	NP_766421
Location (UCSC)	Chr 18: 56.34 – 56.42 Mb	Chr 18: 65.43 – 65.48 Mb
PubMed search

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene.^[1][2][3]

Function

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[4]

Interactions

MALT1 has been shown to interact with BCL10 ^[5] and TRAF6.

Protease substrates

MALT1 is part of the paracaspase family and shows proteolytic activity. Since many of the substrates are involved in regulation of inflammatory responses, the protease activity of MALT1 has emerged as an interesting therapeutic target. Currently known protease substrates are:

• TNFAIP3 (A20)
• BCL10
• CYLD
• NIK (specifically the oncogenic IAP2-MALT1 fusion)
• RELB
• regnase-1

See also

• Paracaspase

References

Further reading

PDB gallery 2g7r: X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1