Lysophosphatidylinositol
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| Names | |
|---|---|
| IUPAC name
[(2R)-2-hydroxy-3-[hydroxy-[(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxypropyl] hexadecanoate | |
| Identifiers | |
| Jmol-3D images | Image |
| PubChem | 71296207 |
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| Properties | |
| Molecular formula |
C25H49O12P |
| Molar mass | 572.62 g·mol−1 |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Infobox references | |
Lysophosphatidylinositol (LPI), or L-α-lysophosphatidylinositol, is an endogenous lysophospholipid and endocannabinoid neurotransmitter. It, along with its 2-arachidonoyl- derivative, have been proposed as the endogenous ligands of GPR55.[1][2][3][4]
See also
References
- ↑ Oka S, Nakajima K, Yamashita A, Kishimoto S, Sugiura T (November 2007). "Identification of GPR55 as a lysophosphatidylinositol receptor". Biochemical and Biophysical Research Communications 362 (4): 928–34. doi:10.1016/j.bbrc.2007.08.078. PMID 17765871.
- ↑ Henstridge CM, Balenga NA, Ford LA, Ross RA, Waldhoer M, Irving AJ (January 2009). "The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 23 (1): 183–93. doi:10.1096/fj.08-108670. PMID 18757503.
- ↑ Piñeiro, Roberto; Falasca, Marco (2012). "Lysophosphatidylinositol signalling: New wine from an old bottle". Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids 1821 (4): 694–705. doi:10.1016/j.bbalip.2012.01.009. PMID 22285325.
- ↑ Oka S, Toshida T, Maruyama K, Nakajima K, Yamashita A, Sugiura T (January 2009). "2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55". Journal of Biochemistry 145 (1): 13–20. doi:10.1093/jb/mvn136. PMID 18845565.
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