Lymphocyte function-associated antigen 1
Lymphocyte function-associated antigen 1, also known as LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor and/or the cytokine receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate. LFA-1/ICAM-1 interaction has recently been shown to be important for T cell-T cell interactions, leading to further T cell differentiation.
LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18). LFA-1 also has a distinct α-chain (αL, CD11a).
See also
Further reading
- Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY
- Parham, Peter, The Immune System 3rd ed. (2009) Garland Science: London and New York
External links
- LFA-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. doi:10.1073/pnas.78.7.4535. PMC 319826. PMID 7027264.
- ITGAL ITGB2 Info with links in the Cell Migration Gateway
- Audrey Gérard, Omar Khan, Peter Beemiller, Erin Oswald, Joyce Hu, Mehrdad Matloubian, Matthew F Krummel (2013). "Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells". Nature Immunology 14: 356–363. doi:10.1038/ni.2547.
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| Calcium-independent | |
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| Calcium-dependent | |
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| Other | |
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- See also
- cell membrane protein disorders
Index of cells |
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| Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
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| Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
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| Alpha | |
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| Beta | |
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| Dimers | Cytoadhesin receptor: | |
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| Fibrinogen receptor: | |
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| Fibronectin receptor: | |
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| Leukocyte-adhesion receptor: | |
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| Very late antigen receptor: |
- Integrin alpha1beta1
- Integrin alpha2beta1
- Integrin alpha3beta1
- VLA-4
- Alpha-5 beta-1
- Integrin alpha6beta1
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| Vitronectin receptor: | |
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| see also cell surface receptor deficiencies
Index of signal transduction |
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| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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