Luis Guzman (disambiguation)

Luis Guzman may refer to:

• Luis Enríquez de Guzmán, 9th Count of Alba de Liste (born circa 1605)
• Luis Muñoz de Guzmán (born 1808), Spanish colonial administrator
• Luis Guzmán (born 28 August 1956), Puerto Rican actor
• Luis Roberto Guzmán (born 1966), Puerto Rican actor