Losoxantrone

Losoxantrone
Clinical data
Identifiers
88303-60-0 Yes
PubChem CID 72116
ChemSpider 65094 Yes
Chemical data
Formula C22H27N5O4
425.48088 g/mol

Losoxantrone (biantrazole) is a anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone.[1][2] It is also sometimes known as DuP 941.[3]

See also

References

  1. ↑ Showalter, H. D. H.; Johnson, J. L.; Hoftiezer, J. M.; Turner, W. R.; Werbel, L. M.; Leopold, W. R.; Shillis, J. L.; Jackson, R. C.; Elslager, E. F. (1987). "Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias". Journal of Medicinal Chemistry 30: 121. doi:10.1021/jm00384a021.
  2. ↑ Beylin, V. G.; Colbry, N. L.; Goel, O. P.; Haky, J. E.; Johnson, D. R.; Johnson, J. L.; Kanter, G. D.; Leeds, R. L.; Leja, B.; Lewis, E. P.; Rithner, C. D.; Showalter, H. D. H.; Sercel, A. D.; Turner, W. R.; Uhlendorf, S. E. (1989). "Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride". Journal of Heterocyclic Chemistry 26: 85. doi:10.1002/jhet.5570260117.
  3. ↑ Leteurtre, F.; Kohlhagen, G.; Paull, K. D.; Pommier, Y. (17 August 1994). "Topoisomerase II Inhibition and Cytotoxicity of the Anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute Preclinical Antitumor Drug Discovery Screen". JNCI Journal of the National Cancer Institute 86 (16): 1239–1244. doi:10.1093/jnci/86.16.1239.