List of people from Tampa, Florida
- Cannonball Adderley (1928-1975), saxophone player
- Nat Adderley (1931–2000), cornet player
- Doug Allen (born 1951), American football player
- T.D. Allman (born 1944), writer, foreign correspondent, historian, author
- Jose Alvarez (born 1956), professional baseball player
- Mike Awesome (1965–2007), professional wrestler
- Jeff Baisley (born 1982), professional baseball player
- George F. Baughman (1915–2004), first president of New College of Florida, rear admiral, USNR
- Derek Bell (born 1968), professional baseball player
- Butch Benton (born 1957), professional baseball player
- Salha "Mama" Bobo (c. 1900 – 2001), Ybor business pioneer
- Ryszard Kukliński polish soldier and CIA agent
- William Brennan (born 1963), professional baseball player
- Evelyn Brent (1899–1975), actress
- Corey Brown (born 1985), professional baseball player
- Bubba the Love Sponge (born 1966) professional broadcaster
- Mike Bynum (born 1978), professional baseball player
- Aaron Carter (born 1987), actor/singer
- Jeff Carter (born 1964), professional baseball player
- Nick Carter (born 1980),singer/One-fifth of the Backstreet Boys
- Kevin Cash (born 1977), professional baseball player
- John Cena (born 1977), professional wrestler
- Ray Charles (1930–2004), blind blues and pops singer, pianist
- Kourtney Compton (born 1991), promotional model and beauty pageant titleholder
- Nardi Contreras (born 1951), professional baseball player
- Tim Crews (born 1961), professional baseball player
- Cory Doyne (born 1981), professional baseball player
- Sam Dyson (born 1988), professional baseball player
- Carl Everett (born 1971), professional baseball player
- Lenny Faedo (born 1960), professional baseball player
- Mike Figga (born 1970), professional baseball player
- Leo Gallagher (born 1947), better known as Gallagher, watermelon-smashing comedian
- Joanna Garcia (born 1979), actress
- Steve Garvey (born 1948), professional baseball player
- Graham Godfrey (born 1984), professional baseball player
- Luis Gonzalez (born 1967), professional baseball player
- Dwight Gooden (born 1964), professional baseball player
- Bob Hall (born 1942), incoming Republican member of the Texas State Senate from Van Zandt County in East Texas
- Garry Hancock (born 1954), professional baseball player
- Jack Harris (born 1941), radio and TV personality, author
- Rondo Hatton (1894-1946), actor/reporter
- Mike Heath (born 1955), professional baseball player
- Hulk Hogan (born 1953), actor/wrestler
- Melissa Howard (born 1977), actress/comedian
- John Hudek (born 1966), professional baseball player
- Lauren Hutton (born 1943), supermodel, actress
- Matt Joyce (born 1984), professional baseball player
- Jill Kelley (born 1975) philanthropist and advocate
- Tony LaRussa (born 1944), professional baseball player
- Tony Little (born 1955), fitness equipment pitchman
- Al Lopez (1908–2005), professional baseball player
- Vance Lovelace (born 1963), professional baseball player
- Dave Magadan (born 1962), professional baseball player
- Matt Mantei (born 1973), professional baseball player
- Sam Marsonek (born 1978), professional baseball player
- Robert Martinez (born 1934), politician, former Governor of Florida
- Tino Martinez (born 1967), professional baseball player
- Billy Mays (1958-2009), TV commercial pitchman
- Eugene McCaslin (born 1977), professional football player
- Lance McCullers (born 1964), professional baseball player
- Tom McEwen (1923-2011), sportswriter
- Fred McGriff (born 1963), professional baseball player
- Butterfly McQueen (1911-1995), actress, Gone with the Wind
- Jason Michaels (born 1976), professional baseball player
- Sam Militello (born 1969), professional baseball player
- Rich Monteleone (born 1963), professional baseball player
- Gene Nelson (born 1960), professional baseball player
- Ralph Onis (1908-1995), professional baseball player
- Ferdie Pacheco (born 1927), physician, boxing analyst
- Sarah Paulson (born 1974), actress
- Lou Piniella (born 1943), professional baseball player
- Rich Puig (born 1953), professional baseball player
- Ryan Raburn (born 1981), professional baseball player
- John Ramos (born 1965), professional baseball player
- Chris Ray (born 1982), professional baseball player
- Jody Reed (born 1962), professional baseball player
- Roy Roberts (born 1906-1975), actor
- Shane Robinson (born 1984), professional baseball player
- Todd Rogers (gamer) (born 1964), electronic sports player
- Jason Romano (born 1979), professional baseball player
- Tony Samuels (1954–2001), gridiron football player
- David Sanborn (born 1945), musician (saxophonist)
- Randy Savage (1952-2011), professional wrestler
- Gary Sheffield (born 1968), professional baseball player
- Brittany Snow (born 1986), actress
- George Steinbrenner (1930-2010), philanthropist, principal owner-New York Yankees
- Stephen Stills (born 1945), singer/songwriter, musician
- John H Sykes businessman and philanthropist, founder of Sykes Enterprises
- Channing Tatum (born 1980), actor
- Ernest Ivy Thomas, Jr. (1924–1945), United States Marine one of six who raised the first flag on Mount Suribachi at the Battle of Iwo Jima
- Santo Trafficante, Jr. (1914–1987), Mafia boss
- Dreama Walker (born 1986), actress
- Mike Williams (born 1984), professional football player
- Charles R. Wilson (born 1954), federal judge
- Tony Zappone (born 1947) journalist, broadcaster, author
- Celph Titled rapper, record producer