| Software | Developer | Applications | Operative system | License | URL |
|---|
| Ariane | ProSim | Utilities management and power plant optimization | | | |
| APMonitor | | Data reconciliation, real-time optimization, dynamic simulation and nonlinear predictive control | | | |
| Aspen Plus | Aspen Technology | Process simulation and optimization | | | |
| Aspen HYSYS | Aspen Technology | Process simulation and optimization | | | |
| ASSETT | Kongsberg Oil & Gas Technologies AS | Dynamic process simulation | | | |
| BatchColumn | ProSim | Simulation and Optimization of batch distillation columns | | | |
| BatchReactor | ProSim | Simulation of chemical reactors in batch mode | | | |
| D-SPICE | Kongsberg Oil & Gas Technologies AS | | | | |
| K-Spice | Kongsberg Oil & Gas Technologies AS | Dynamic process simulation and multiphase pipeline simulation | | | |
| CADSIM Plus | Aurel Systems Inc. | Steady-state and dynamic process simulation | | | |
| ChromWorks | ChromWorks, Inc. | Continuous/Batch chromatography process simulator | | | |
| CHEMCAD | Chemstations | Software suite for process simulation | | | |
| Cycle-Tempo | Asimptote | Thermodynamic analysis and optimization of systems for the production of electricity, heat and refrigeration | | | |
| COCO simulator | AmsterCHEM | Steady state simulation | | free of charge | |
| Design II for Windows | WinSim Inc. | Process simulation | | | |
| Distillation expert trainer | ATR | Operator training simulator for distillation process | | | |
| DWSIM | Daniel Medeiros, Gustavo León and Gregor Reichert | Process simulator | Windows, Linux, Mac | open-source | |
| DynoChem | Scale-up Systems Ltd. | | | | |
| EMSO | ALSOC Project | Modelling, simulation and optimisation | Windows, Linux | ALSOC License |
|
| Dymola | CATIA Systems Engineering | Dynamic modelling and simulation software | | | |
| Flowtran simulation | Monsanto | | | | |
| gPROMS | PSE Ltd | Advanced process simulation and modelling | | | |
| HSC Sim | Outotec Oyj | Advanced process simulation and modelling, Flowsheet simulation | Windows | | |
| HYDROFLO | Tahoe Design Software | Piping System Design with Steady State Analysis | Windows | Free Academic -Std Commercial | |
| INDISS | RSI | | | | |
| ICAS: integrated computer-aided system | CAPEC | | | | |
| IDEAS | Andritz Automation | | | | |
| iiSE Simulator | VRTech | | | | |
| LIBPF | | C++ LIBrary for process flowsheeting | | | |
| JModelica.org | Modelon AB | | | open-source | |
| METSIM | Proware | General-purpose dynamic and steady state process simulation system | Windows | | |
| Mimic | MYNAH Technologies | First-principles dynamic simulator built for software acceptance testing and operator training systems | | |
|
| Mobatec Modeller | Mobatec | | | | |
| NAPCON ProsDS | Neste Jacobs Oy | Dynamic process simulation | Windows | | |
| Clearview | Mapjects | | | | |
| OLGA | SPT Group (Schlumberger) | | | | |
| Omegaland | Yokogawa | | | | |
| OpenModelica | Open-Source Modelica Consortium | | | open-source | |
| PIPE-FLO Professional | Engineered Software Inc. | | | | |
| PEL Software Suite | | | | | |
| Petro-SIM | KBC Advanced Technologies | | | | |
| PETROX | Petrobras | General Purpose, Static, Sequential-Modular Process Simulator | Windows | internal users only | |
| Prode Properties | Prode Software | | | | |
| Prode simulator | Prode Software | | | | |
| ProSim DAC | ProSim | Dynamic Adsorption Column Simulation | | | |
| ProSimPlus | ProSim | Process simulation and optimization | | | |
| ProSimulator | Sim Infosystems | | | | |
| Pro-Steam | KBC Advanced Technologies | | | | |
| ProMax | Bryan Research and Engineering | | | | |
| TSWEET | Bryan Research and Engineering | | | | |
| PROSIM | | | | | |
| PRO/II | SimSci | | | | |
| DYNSIM | SimSci | | | | |
| ROMeo (process optimizer) | SimSci | | | | |
| RecoVR | VRTech | | | | |
| Simulis Thermodynamics | ProSim | Mixture properties and fluid phase equilibria calculations | | | |
| SimCreate | TSC Simulation | | | | |
| SPEEDUP | Roger W.H. Sargent and students | | | | |
| SolidSim | SolidSim Engineering GmbH | Flowsheet simulation of solids processes | | | |
| SuperPro Designer | Intelligen | | | | |
| SysCAD | | | | | |
| System7 | Epcon International | | | | |
| UniSim design | Honeywell | | | | |
| Shadow plant | Honeywell | | | | |
| Usim Pac | Caspeo | | | | |
| VMGSim | Virtual Materials Group | | | | |
| Wolfram SystemModeler | Wolfram Research | | Windows, Mac, Linux | | |
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