List of Interstate Highways in Mississippi

Highway names
Standard route shields
Interstates:	Interstate X (I-X)
US Routes:	U.S. Route X (US X)
State:	Mississippi Highway X (MS X)
System links
Numbered Highways in Mississippi Interstates US State Unsigned

In the U.S. state of Mississippi, Interstate Highways are maintained by the Mississippi Department of Transportation (MDOT).

List of Interstate Highways

	Interstate 10 Santa Monica, California, to Jacksonville, Florida Crosses the Louisiana state line west of Diamondhead; crosses the Alabama state line near Missala
	Interstate 20 Kent, Texas, to Florence, South Carolina Crosses the Louisiana state line near Vicksburg; crosses the Alabama state line near Kewanee
	Interstate 22 Memphis, Tennessee, to Birmingham, Alabama Proposed interstate highway following the current US 78 corridor
	Interstate 55 La Place, Louisiana, to Chicago, Illinois Crosses the Louisiana state line near Osyka; crosses the Tennessee state line near Southaven
	Interstate 59 Slidell, Louisiana, to Lookout Mountain, Georgia Crosses the Louisiana state line near Nicholson; crosses the Alabama state line near Kewanee
	Interstate 69 Indianapolis, Indiana, to Port Huron, Michigan; proposed extension south to the Mexico border in Texas Proposed interstate highway crossing the Arkansas state line near Benoit, Mississippi, and crossing the Tennessee state line near Southaven, Mississippi. A section between Robinsonville and Hernando is open and signed.
	Interstate 110 Biloxi, Mississippi
	Interstate 220 Jackson to Ridgeland, Mississippi Beltway around northwestern Jackson
	Interstate 269 Hernando, Mississippi, to Millington, Tennessee Proposed outer beltway of Memphis