Liprin-alpha-1

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPPFIA1 ; LIP.1; LIP1; LIPRIN
External IDsOMIM: 611054 MGI: 1924750 HomoloGene: 20802 GeneCards: PPFIA1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez8500233977
EnsemblENSG00000131626ENSMUSG00000037519
UniProtQ13136B2RXQ2
RefSeq (mRNA)NM_003626NM_001033319
RefSeq (protein)NP_003617NP_001028491
Location (UCSC)Chr 11:
70.12 – 70.23 Mb		Chr 7:
144.48 – 144.55 Mb
PubMed search

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.[3]

Interactions

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J 14 (12): 2827–2838. PMC 398401. PMID 7796809. Vancouver style error (help)
  2. ↑ 2.0 2.1 2.2 2.3 Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem 273 (25): 15611–15620. doi:10.1074/jbc.273.25.15611. PMID 9624153. Vancouver style error (help)
  3. ↑ 3.0 3.1 "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1".
  4. ↑ 4.0 4.1 4.2 Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
  5. ↑ 5.0 5.1 Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M et al. (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. PMID 12629171.
  6. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  7. ↑ 7.0 7.1 7.2 Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829. Vancouver style error (help)

Further reading