Levopimaradiene synthase
| Levopimaradiene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.32 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with system name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming).[1][2] This enzyme catalyses the following chemical reaction
- (+)-copalyl diphosphate
abieta-8(14),12-diene + diphosphate
In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.
References
- ↑ Schepmann, H.G., Pang, J. and Matsuda, S.P. (2001). "Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis". Arch. Biochem. Biophys. 392 (2): 263–269. doi:10.1006/abbi.2001.2438. PMID 11488601.
- ↑ Ro, D.K. and Bohlmann, J. (2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry 67: 1572–1578. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345.
External links
- Levopimaradiene synthase at the US National Library of Medicine Medical Subject Headings (MeSH)