Leucine-responsive regulatory protein

Leucine responsive protein, or Lrp,[1] is a global regulator protein, meaning that it regulates the biosynthesis of leucine, as well as the other branched-chain amino acids, valine and isoleucine. In bacteria, it is encoded by the lrp gene.

Lrp alternatively activates and represses the expression of acetolactate synthase's (ALS) several isoenzymes. Lrp, in E. coli, along with DAM plays a role in the regulation of the pap operon, pylonephritis associated pili.


References

  1. ↑ de los Rios S, Perona JJ (March 2007). "Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly". J. Mol. Biol. 366 (5): 1589–602. doi:10.1016/j.jmb.2006.12.032. PMC 1933502. PMID 17223133.

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