Leu-enkephalin
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Names | |
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IUPAC names
(2R)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3- (4-hydroxyphenyl)propanoyl]amino]acetyl] amino]acetyl]amino]-3-phenylpropanoyl] amino]-4-methylpentanoic acid | |
Identifiers | |
58822-25-6 ![]() | |
ChEMBL | ChEMBL8234 ![]() |
ChemSpider | 406229 ![]() |
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IUPHAR ligand | 1613 |
Jmol-3D images | Image |
PubChem | 461776 |
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Properties | |
C28H37N5O7 | |
Molar mass | 555.62268 g/mol |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
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Infobox references | |
Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine. Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.
See also
References
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