Lecithin—cholesterol acyltransferase

Lecithin-cholesterol acyltransferase

Identifiers

External IDs

OMIM: 606967 MGI: 96755 HomoloGene: 68042 ChEMBL: 5942 GeneCards: LCAT Gene

2.3.1.43

Gene ontology
Molecular function	• phosphatidylcholine-sterol O-acyltransferase activity • protein binding • apolipoprotein A-I binding
Cellular component	• extracellular region • extracellular space • high-density lipoprotein particle • extracellular vesicular exosome
Biological process	• phospholipid metabolic process • phosphatidylcholine biosynthetic process • cholesterol metabolic process • cholesterol transport • very-low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling • cholesterol esterification • lipoprotein metabolic process • lipoprotein biosynthetic process • cholesterol homeostasis • reverse cholesterol transport • small molecule metabolic process • regulation of high-density lipoprotein particle assembly
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
67.97 – 67.98 Mb

Chr 8:
105.94 – 105.94 Mb

PubMed search

Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Statin Pathway edit|]]

Statin Pathway edit

↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

External links

Lecithin Cholesterol Acyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups

acetyltransferases: Acetyl-Coenzyme A acetyltransferase
N-Acetylglutamate synthase
Choline acetyltransferase
Dihydrolipoyl transacetylase
Acetyl-CoA C-acyltransferase
Beta-galactoside transacetylase
Chloramphenicol acetyltransferase
N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
Histone acetyltransferase
- P300/CBP
- NAT2

palmitoyltransferases: Carnitine O-palmitoyltransferase
- CPT1
- CPT2
Serine C-palmitoyltransferase
- SPTLC1
- SPTLC2

2.3.2: Aminoacyltransferases

2.3.3: converted into alkyl on transfer

Biochemistry overview
Enzymes overview
By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
2.1
- 2
- 3
- 4
- 5
- 6
- 7
  - 2.7.10
  - 11-12
- 8
3.1
- - 3.1.3.48
- 2
- 3
- 4
  - 3.4.21
  - 22
  - 23
  - 24
- 5
- 6
- 7
4.1
- 2
- 3
- 4
- 5
- 6
5.1
- 2
- 3
- 4
- 99
6.1-3
- 4
- 5-6

Lipids: lipoprotein particle metabolism

Lipoprotein particle classes and subclasses

delivery of TGs: Chylomicron
VLDL

delivery of C and CE: IDL
LDL
lb LDL
sd LDL
Lp(a)
HDL

Apolipoproteins

APOA
- 1
- 2
- 4
- 5
APOB
APOC
- 1
- 2
- 3
- 4
APOD
APOE
APOH

SAA
- SAA1

Extracellular enzymes

Lipid transfer proteins

Cell surface receptors

HDL: SCARB1

IDL: LRP
- LRP1
- LRP1B
- LRP2
- LRP3
- LRP4
- LRP5
- LRP5L
- LRP6
- LRP8
- LRP10
- LRP11
- LRP12

LDL: LDLR
LRPAP1

ATP-binding cassette transporter

Index of inborn errors of metabolism

Description	Metabolism Enzymes and pathways: citric acid cycle enzymes pentose phosphate intermediates glycoproteins enzymes glycosaminoglycans proteoglycan enzymes phospholipid metabolism cholesterol and steroid intermediates sphingolipids enzymes eicosanoids enzymes amino acid intermediates urea cycle enzymes nucleotide intermediates

Disorders	Citric acid cycle and electron transport chain Glycoprotein Proteoglycan Fatty-acid Phospholipid Cholesterol and steroid Eicosanoid Amino acid Purine-pyrimidine Heme metabolism Symptoms and signs

Treatment	Drugs other

Lecithin—cholesterol acyltransferase

Interactive pathway map

See also

References

Further reading

External links