Latent TGF-beta binding protein

The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.[1][2]

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

latent transforming growth factor beta binding protein 1
Identifiers
Symbol LTBP1
Alt. symbols TGF-beta1-BP-1
Entrez 4052
HUGO 6714
OMIM 150390
RefSeq NM_206943
UniProt Q14766
Other data
Locus Chr. 2 p22-p21
latent transforming growth factor beta binding protein 2
Identifiers
Symbol LTBP2
Alt. symbols LTBP3, C14orf141
Entrez 4053
HUGO 6715
OMIM 602091
RefSeq NM_000428
UniProt Q14767
Other data
Locus Chr. 14 q24.3
latent transforming growth factor beta binding protein 3
Identifiers
Symbol LTBP3
Alt. symbols LTBP2
Entrez 4054
HUGO 6716
OMIM 602090
RefSeq NM_021070
UniProt Q9NS15
Other data
Locus Chr. 11 q12
latent transforming growth factor beta binding protein 4
Identifiers
Symbol LTBP4
Alt. symbols LTBP-4, LTBP-4L
Entrez 8425
HUGO 6717
OMIM 604710
RefSeq NM_003573
UniProt Q8N2S1
Other data
Locus Chr. 19 q13.1-13.2

References

  1. ↑ Rifkin DB (March 2005). "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability". J. Biol. Chem. 280 (9): 7409–12. doi:10.1074/jbc.R400029200. PMID 15611103.
  2. ↑ Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB (January 2005). "Latent TGF-beta binding proteins". Int. J. Biochem. Cell Biol. 37 (1): 38–41. doi:10.1016/j.biocel.2004.03.011. PMID 15381147.

External links