LSM7
| LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LSM7 ; YNL147W | ||||||||||||
| External IDs | OMIM: 607287 MGI: 1913344 HomoloGene: 6781 GeneCards: LSM7 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51690 | 66094 | |||||||||||
| Ensembl | ENSG00000130332 | ENSMUSG00000035215 | |||||||||||
| UniProt | Q9UK45 | Q9CQQ8 | |||||||||||
| RefSeq (mRNA) | NM_016199 | NM_025349 | |||||||||||
| RefSeq (protein) | NP_057283 | NP_079625 | |||||||||||
| Location (UCSC) | Chr 19: 2.32 – 2.33 Mb | Chr 10: 78.39 – 78.39 Mb | |||||||||||
| PubMed search | |||||||||||||
U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.[1][2][3]
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][3]
Interactions
LSM7 has been shown to interact with TACC1[4][5] and LSM2.[6][7]
References
- ↑ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
- ↑ Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA 8 (12): 1489–501. PMC 1370355. PMID 12515382.
- ↑ 3.0 3.1 "Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
- ↑ Conte, Nathalie; Delaval Bénédicte; Ginestier Christophe; Ferrand Alexia; Isnardon Daniel; Larroque Christian; Prigent Claude; Séraphin Bertrand; Jacquemier Jocelyne; Birnbaum Daniel (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene (England) 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. ISSN 0950-9232. PMID 14603251.
- ↑ Conte, Nathalie; Charafe-Jauffret Emmanuelle, Delaval Bénédicte, Adélaïde José, Ginestier Christophe, Geneix Jeannine, Isnardon Daniel, Jacquemier Jocelyne, Birnbaum Daniel (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene (England) 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. ISSN 0950-9232. PMID 12165861.
- ↑ Lehner, Ben; Sanderson Christopher M (Jul 2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. (United States) 14 (7): 1315–23. doi:10.1101/gr.2122004. ISSN 1088-9051. PMC 442147. PMID 15231747.
- ↑ Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics (United States) 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819.
Further reading
- Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
- Suzuki H, Fukunishi Y, Kagawa I et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
- Eystathioy T, Peebles CL, Hamel JC et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
- Conte N, Charafe-Jauffret E, Delaval B et al. (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Conte N, Delaval B, Ginestier C et al. (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
- Lehner B, Semple JI, Brown SE et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC 2172029. PMID 15452143.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.