LMTK2

Lemur tyrosine kinase 2
Identifiers
SymbolsLMTK2 ; AATYK2; BREK; KPI-2; KPI2; LMR2; PPP1R100; cprk
External IDsOMIM: 610989 MGI: 3036247 HomoloGene: 8948 IUPHAR: 2056 GeneCards: LMTK2 Gene
EC number2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez22853231876
EnsemblENSG00000164715ENSMUSG00000038970
UniProtQ8IWU2Q3TYD6
RefSeq (mRNA)NM_014916NM_001081109
RefSeq (protein)NP_055731NP_001074578
Location (UCSC)Chr 7:
97.74 – 97.84 Mb
Chr 5:
144.1 – 144.19 Mb
PubMed search

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.[1][2]

Function

The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.[2]

Interactions

LMTK2 has been shown to interact with PPP1CA,[3] Cyclin-dependent kinase 5[4] and PPP1R2.[3]

References

  1. Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling". Genes Cells 9 (3): 219–32. doi:10.1111/j.1356-9597.2004.00714.x. PMID 15005709.
  2. 2.0 2.1 "Entrez Gene: LMTK2 lemur tyrosine kinase 2".
  3. 3.0 3.1 Wang, Hong; Brautigan David L (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. (United States) 277 (51): 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858.
  4. Kesavapany, Sashi; Lau Kwok-Fai; Ackerley Steven; Banner Steven J; Shemilt Stephen J A; Cooper Jonathan D; Leigh P Nigel; Shaw Christopher E; McLoughlin Declan M; Miller Christopher C J (Jun 2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase". J. Neurosci. (United States) 23 (12): 4975–83. PMID 12832520.

Further reading

  • Eeles RA, Kote-Jarai Z, Giles GG et al. (2008). "Multiple newly identified loci associated with prostate cancer susceptibility.". Nat. Genet. 40 (3): 316–21. doi:10.1038/ng.90. PMID 18264097.
  • Chibalina MV, Seaman MN, Miller CC et al. (2008). "Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.". J. Cell. Sci. 120 (Pt 24): 4278–88. doi:10.1242/jcs.014217. PMC 2621362. PMID 18029400.
  • Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Wang H, Brautigan DL (2007). "Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase.". Mol. Cell Proteomics 5 (11): 2124–30. doi:10.1074/mcp.M600188-MCP200. PMID 16887929.
  • Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Kesavapany S, Lau KF, Ackerley S et al. (2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.". J. Neurosci. 23 (12): 4975–83. PMID 12832520.
  • Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.". J. Biol. Chem. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
  • Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.