LINGO1
| Leucine rich repeat and Ig domain containing 1 | |||||||||||||
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 PDB rendering based on 2id5. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LINGO1 ; LERN1; LRRN6A; UNQ201 | ||||||||||||
| External IDs | OMIM: 609791 MGI: 1915522 HomoloGene: 41891 GeneCards: LINGO1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 84894 | 235402 | |||||||||||
| Ensembl | ENSG00000169783 | ENSMUSG00000049556 | |||||||||||
| UniProt | Q96FE5 | Q9D1T0 | |||||||||||
| RefSeq (mRNA) | NM_001301186 | NM_181074 | |||||||||||
| RefSeq (protein) | NP_001288115 | NP_851419 | |||||||||||
| Location (UCSC) | Chr 15: 77.91 – 78.11 Mb | Chr 9: 56.62 – 56.69 Mb | |||||||||||
| PubMed search | |||||||||||||
Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a protein which in humans is encoded by the LINGO1 gene.[1][2]
Structure
LINGO-1 contains an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail.[2][3]
LINGO-1 interacts with the Nogo receptor.[3]
Function
LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system.[3] LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require p75 or NgR1.
Recent post mortem studies have evidenced an increase in LINGO1 in the cerebellum of people with essential tremor.[4][5]
References
- ↑ "Entrez Gene: LINGO1 leucine rich repeat and Ig domain containing 1".
- ↑ 2.0 2.1 Carim-Todd L, Escarceller M, Estivill X, Sumoy L (December 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". Eur. J. Neurosci. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891.
- ↑ 3.0 3.1 3.2 Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J et al. (March 2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex". Nat. Neurosci. 7 (3): 221–8. doi:10.1038/nn1188. PMID 14966521.
- ↑ Delay C, Tremblay C, Brochu E, Paris-Robidas S, Emond V, Rajput AH et al. (2014). "Increased LINGO1 in the cerebellum of essential tremor patients". Mov Disord. doi:10.1002/mds.25819. PMID 24531928.
- ↑ Kuo SH, Tang G, Louis ED, Ma K, Babji R, Balatbat M et al. (2013). "Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau". Acta Neuropathol 125 (6): 879–89. doi:10.1007/s00401-013-1108-7. PMID 23543187.
Further reading
- Carim-Todd L, Escarceller M, Estivill X, Sumoy L (2004). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". Eur. J. Neurosci. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891.
- Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J et al. (2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex". Nat. Neurosci. 7 (3): 221–8. doi:10.1038/nn1188. PMID 14966521.
- Shao Z, Browning JL, Lee X, Scott ML, Shulga-Morskaya S, Allaire N et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration". Neuron 45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID 15694322.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A et al. (2007). "The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition". J. Biol. Chem. 281 (47): 36378–90. doi:10.1074/jbc.M607314200. PMID 17005555.
- Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol. 33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID 17239012.
- Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P et al. (2007). "Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14430–5. doi:10.1073/pnas.0700901104. PMC 1955463. PMID 17726113.
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