LATS2

Large tumor suppressor kinase 2
Identifiers
SymbolsLATS2 ; KPM
External IDsOMIM: 604861 MGI: 1354386 HomoloGene: 56678 IUPHAR: 1516 ChEMBL: 5907 GeneCards: LATS2 Gene
EC number2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2652450523
EnsemblENSG00000150457ENSMUSG00000021959
UniProtQ9NRM7Q7TSJ6
RefSeq (mRNA)NM_014572NM_015771
RefSeq (protein)NP_055387NP_056586
Location (UCSC)Chr 13:
21.55 – 21.64 Mb		Chr 14:
57.64 – 57.76 Mb
PubMed search

Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.[1][2]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.[2]

References

  1. ↑ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
  2. ↑ 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

Further reading

  • Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor.". Oncogene 19 (27): 3101–9. doi:10.1038/sj.onc.1203659. PMID 10871863.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Li Y, Pei J, Xia H et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition.". Oncogene 22 (28): 4398–405. doi:10.1038/sj.onc.1206603. PMID 12853976.
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Powzaniuk M, McElwee-Witmer S, Vogel RL et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.". Mol. Endocrinol. 18 (8): 2011–23. doi:10.1210/me.2004-0065. PMID 15131260.
  • Toji S, Yabuta N, Hosomi T et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.". Genes Cells 9 (5): 383–97. doi:10.1111/j.1356-9597.2004.00732.x. PMID 15147269.
  • Ke H, Pei J, Ni Z et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).". Exp. Cell Res. 298 (2): 329–38. doi:10.1016/j.yexcr.2004.04.031. PMID 15265683.
  • Chan EH, Nousiainen M, Chalamalasetty RB et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
  • Takahashi Y, Miyoshi Y, Takahata C et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.". Clin. Cancer Res. 11 (4): 1380–5. doi:10.1158/1078-0432.CCR-04-1773. PMID 15746036.
  • Abe Y, Ohsugi M, Haraguchi K et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis.". FEBS Lett. 580 (3): 782–8. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.
  • Voorhoeve PM, le Sage C, Schrier M et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.". Cell 124 (6): 1169–81. doi:10.1016/j.cell.2006.02.037. PMID 16564011.
  • Aylon Y, Michael D, Shmueli A et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.". Genes Dev. 20 (19): 2687–700. doi:10.1101/gad.1447006. PMC 1578695. PMID 17015431.
  • Jiang Z, Li X, Hu J et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.". Neurosci. Res. 56 (4): 450–8. doi:10.1016/j.neures.2006.09.006. PMID 17049657.