LAMP1
Lysosomal-associated membrane protein 1 (LAMP1) also known as CD107a (Cluster of Differentiation 107a)
, is a human gene.[1]
The protein encoded by this gene is a member of the family of Lysosome-associated membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.[1] CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.
See also
References
Further reading
- Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". J. Biol. Regul. Homeost. Agents 16 (2): 147–51. PMID 12144129.
- Schleutker J, Haataja L, Renlund M et al. (1992). "Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease". Hum. Genet. 88 (1): 95–7. doi:10.1007/BF00204936. PMID 1959930.
- Carlsson SR, Fukuda M (1990). "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones". J. Biol. Chem. 265 (33): 20488–95. PMID 2243102.
- Mattei MG, Matterson J, Chen JW et al. (1990). "Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively". J. Biol. Chem. 265 (13): 7548–51. PMID 2332441.
- Carlsson SR, Fukuda M (1990). "Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement". J. Biol. Chem. 264 (34): 20526–31. PMID 2584229.
- Mane SM, Marzella L, Bainton DF et al. (1989). "Purification and characterization of human lysosomal membrane glycoproteins". Arch. Biochem. Biophys. 268 (1): 360–78. doi:10.1016/0003-9861(89)90597-3. PMID 2912382.
- Viitala J, Carlsson SR, Siebert PD, Fukuda M (1988). "Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000". Proc. Natl. Acad. Sci. U.S.A. 85 (11): 3743–7. doi:10.1073/pnas.85.11.3743. PMC 280294. PMID 3131762.
- Howe CL, Granger BL, Hull M et al. (1988). "Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins". Proc. Natl. Acad. Sci. U.S.A. 85 (20): 7577–81. doi:10.1073/pnas.85.20.7577. PMC 282235. PMID 3174652.
- Fukuda M, Viitala J, Matteson J, Carlsson SR (1989). "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences". J. Biol. Chem. 263 (35): 18920–8. PMID 3198605.
- Ohno H, Stewart J, Fournier MC et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.
- Carlsson SR, Lycksell PO, Fukuda M (1993). "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2". Arch. Biochem. Biophys. 304 (1): 65–73. doi:10.1006/abbi.1993.1322. PMID 8323299.
- Sawada R, Jardine KA, Fukuda M (1993). "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes". J. Biol. Chem. 268 (12): 9014–22. PMID 8517882.
- Rohrer J, Schweizer A, Russell D, Kornfeld S (1996). "The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane". J. Cell Biol. 132 (4): 565–76. doi:10.1083/jcb.132.4.565. PMC 2199866. PMID 8647888.
- Höning S, Sandoval IV, von Figura K (1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3". EMBO J. 17 (5): 1304–14. doi:10.1093/emboj/17.5.1304. PMC 1170479. PMID 9482728.
- Furuta K, Yang XL, Chen JS et al. (1999). "Differential expression of the lysosome-associated membrane proteins in normal human tissues". Arch. Biochem. Biophys. 365 (1): 75–82. doi:10.1006/abbi.1999.1147. PMID 10222041.
- Raposo G, Moore M, Innes D et al. (2003). "Human macrophages accumulate HIV-1 particles in MHC II compartments". Traffic 3 (10): 718–29. doi:10.1034/j.1600-0854.2002.31004.x. PMID 12230470.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
|---|
| | 1-50 | |
|---|
| | 51-100 | |
|---|
| | 101-150 | |
|---|
| | 151-200 | |
|---|
| | 201-250 | |
|---|
| | 251-300 | |
|---|
| | 301-350 | |
|---|
|
|
|---|
| | Enzymes | |
|---|
| | Transporters | |
|---|
| | Structure/Peroxin | |
|---|
| | LAMP | |
|---|
| see also intermediates, disorders
Index of cells |
|---|
| | Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
|
|---|
| | Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
|
|---|
|
|
