LAG3
| Lymphocyte-activation gene 3 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LAG3 ; CD223 | ||||||||||||
| External IDs | OMIM: 153337 MGI: 106588 HomoloGene: 1719 GeneCards: LAG3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3902 | 16768 | |||||||||||
| Ensembl | ENSG00000089692 | ENSMUSG00000030124 | |||||||||||
| UniProt | P18627 | Q61790 | |||||||||||
| RefSeq (mRNA) | NM_002286 | NM_008479 | |||||||||||
| RefSeq (protein) | NP_002277 | NP_032505 | |||||||||||
| Location (UCSC) | Chr 12: 6.88 – 6.89 Mb | Chr 6: 124.9 – 124.91 Mb | |||||||||||
| PubMed search | |||||||||||||
Lymphocyte-activation gene 3, also known as LAG3, is a protein which in humans is encoded by the LAG3 gene.[1][2] LAG3 has also recently been designated CD223 (cluster of differentiation 223).
Lymphocyte-activation protein 3 belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: LAG3 lymphocyte-activation gene 3".
- ↑ Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E, Hercend T (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078.
Further reading
- Triebel F (2004). "LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination". Trends Immunol. 24 (12): 619–22. doi:10.1016/j.it.2003.10.001. PMID 14644131.
- Baixeras E; Huard B; Miossec C et al. (1992). "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens". J. Exp. Med. 176 (2): 327–37. doi:10.1084/jem.176.2.327. PMC 2119326. PMID 1380059.
- Triebel F; Jitsukawa S; Baixeras E et al. (1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. doi:10.1084/jem.171.5.1393. PMC 2187904. PMID 1692078.
- Blum MD; Wong GT; Higgins KM et al. (1993). "Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer". J. Exp. Med. 177 (5): 1343–58. doi:10.1084/jem.177.5.1343. PMC 2191022. PMID 8097522.
- Huard B; Mastrangeli R; Prigent P et al. (1997). "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5744–9. doi:10.1073/pnas.94.11.5744. PMC 20850. PMID 9159144.
- Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus". Immunogenetics 47 (1): 96–8. doi:10.1007/s002510050332. PMID 9382927.
- Bruniquel D, Borie N, Hannier S, Triebel F (1998). "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II". Immunogenetics 48 (2): 116–24. doi:10.1007/s002510050411. PMID 9634475.
- Hannier S, Tournier M, Bismuth G, Triebel F (1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling". J. Immunol. 161 (8): 4058–65. PMID 9780176.
- Hannier S, Triebel F (1999). "The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes". Int. Immunol. 11 (11): 1745–52. doi:10.1093/intimm/11.11.1745. PMID 10545478.
- Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway". Eur. J. Immunol. 31 (10): 2885–91. doi:10.1002/1521-4141(2001010)31:10<2885::AID-IMMU2885>3.0.CO;2-2. PMID 11592063.
- Andreae S, Piras F, Burdin N, Triebel F (2002). "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)". J. Immunol. 168 (8): 3874–80. doi:10.4049/jimmunol.168.8.3874. PMID 11937541.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Andreae S, Buisson S, Triebel F (2003). "MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223)". Blood 102 (6): 2130–7. doi:10.1182/blood-2003-01-0273. PMID 12775570.
- Cai XF; Tao Z; Yan ZQ et al. (2004). "Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family". DNA Seq. 14 (2): 79–86. doi:10.1080/1042517021000041831. PMID 12825348.
- Gandhi MK; Lambley E; Duraiswamy J et al. (2006). "Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients". Blood 108 (7): 2280–9. doi:10.1182/blood-2006-04-015164. PMID 16757686.
- Lundmark F; Harbo HF; Celius EG et al. (2007). "Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations". J. Neuroimmunol. 180 (1–2): 193–8. doi:10.1016/j.jneuroim.2006.08.009. PMID 17020785.
External links
- LAG3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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