L-myc internal ribosome entry site (IRES)
| L-myc internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_L-myc | |
| Identifiers | |
| Symbol | IRES_L-myc |
| Rfam | RF00261 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | 0043022 |
| SO | 0000243 |
The L-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of L-myc that allows cap-independent translation. L-myc undergoes translation via the internal ribosome entry site and bypasses the typical eukaryotic cap-dependent translation pathway [1]. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis.
References
- [1] Jopling, CL; Spriggs KA; Mitchell SA; Stoneley M; Willis AE (2004). "L-Myc protein synthesis is initiated by internal ribosome entry". RNA 10 (2): 287–298. doi:10.1261/rna.5138804. PMC 1370540. PMID 14730027.