Krüppel

Krüppel is a gap gene originally described in Drosophila melanogaster, which encodes a zinc finger transcription factor with four tandemly repeated zinc finger domains.^[1]

Krüppel means, literally, "cripple" in German, named for the crippled appearance of mutant larva. Krüppel regulates the expression of several other gap genes.^[2]

See also Kruppel-like factors which have been recently investigated in the heart but are well characterized for their role in carcinogenesis.

References

1. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 165220
2. ↑ Interactive Fly, Drosophila

External links

• Diagram at Davidson College - a Drosophila embryo at the cellular blastoderm stage triple-labeled for three segmentation proteins including Krüppel (in blue) Hairy (green) and Giant (red).
• Kruppel protein, Drosophila at the US National Library of Medicine Medical Subject Headings (MeSH)