Kexin

For the Chinese gymnast, see He Kexin.
Kex2p
Identifiers
Symbol KEX2
Entrez 855483
UniProt D6W0V5
Other data
EC number 3.4.21.61

Kexin (EC 3.4.21.61, yeast KEX2 protease, proteinase yscF, prohormone-processing endoprotease, paired-basic endopeptidase, yeast cysteine proteinase F, paired-basic endopeptidase, andrenorphin-Gly-generating enzyme, endoproteinase Kex2p, gene KEX2 dibasic proteinase, Kex 2p proteinase, Kex2 endopeptidase, Kex2 endoprotease, Kex2 endoproteinase, Kex2 protease, proteinase Kex2p, Kex2-like precursor protein processing endoprotease, prohormone-processing KEX2 proteinase, prohormone-processing proteinase, proprotein convertase, protease KEX2, Kex2 proteinase, Kex2-like endoproteinase) is a prohormone processing protease found in the budding yeast (S. cerevisiae) that shares structural similarities with the bacterial protease subtilisin.[1][2][3][4][5][6] It is encoded by the yeast gene KEX2 and usually referred to in the scientific community as Kex2p. The first mammalian homologue of this protein to be identified was furin. This enzyme catalyses the following chemical reaction

Cleavage of -Lys-Arg- and -Arg-Arg- bonds to process yeast alpha-factor pheromone and killer toxin precursors.

References

  1. ↑ Rockwell NC, Krysan DJ, Komiyama T, Fuller RS (December 2002). "Precursor processing by kex2/furin proteases". Chem. Rev. 102 (12): 4525–48. doi:10.1021/cr010168i. PMID 12475200.
  2. ↑ Julius, D., Brake, A., Blair, L., Kunisawa, R. and Thorner, J. (1984). "Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor". Cell 37: 1075–1089. doi:10.1016/0092-8674(84)90442-2. PMID 6430565.
  3. ↑ Achstetter, T. and Wolf, D.H. (1985). "Hormone processing and membrane-bound proteinases in yeast". EMBO J. 4: 173–177. PMID 3894003.
  4. ↑ Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S. and Matsuo, H. (1988). "Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases". Biochem. Biophys. Res. Commun. 156: 246–254. doi:10.1016/s0006-291x(88)80832-5. PMID 2845974.
  5. ↑ Fuller, R.S., Brake, A. and Thorner, J. (1989). "Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease". Proc. Natl. Acad. Sci. USA 86: 1434–1438. doi:10.1073/pnas.86.5.1434. PMID 2646633.
  6. ↑ Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S. and Matsuo, H. (1989). "Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae". Biochem. Biophys. Res. Commun. 159: 305–311. doi:10.1016/0006-291x(89)92438-8. PMID 2647083.

External links