Ketipramine

Ketipramine
Systematic (IUPAC) name
5-[3-(dimethylamino)propyl]-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one
Clinical data
Oral
Identifiers
17243-32-2
None
PubChem CID 28424
ChemSpider 26443
UNII U5C4H63K5U
Chemical data
Formula C19H22N2O
294.39 g/mol

Ketipramine (G-35,259), also known as ketimipramine or ketoimipramine, is a tricyclic antidepressant (TCA) that was tested in clinical trials for the treatment of depression in the 1960s but was never marketed.[1][2][3] It differs from imipramine in terms of chemical structure only by the addition of a ketone group, to the azepine ring, and is approximately equivalent in effectiveness as an antidepressant in comparison.[4]

See also

References

  1. ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  2. ↑ Simeon J, Fuchs M, Nikolovski O, Bucci L (1970). "Ketipramine in the therapy of depression in outpatients". Psychosomatics 11 (4): 342–6. doi:10.1016/S0033-3182(70)71634-4. PMID 5459338.
  3. ↑ Park S, Glick B, Floyd A, Gershon S (May 1971). "Ketipramine fumarate as compared to imipramine in depressed outpatients". Current Therapeutic Research, Clinical and Experimental 13 (5): 322–5. PMID 4998396.
  4. ↑ Author Unknown (1971). Ann Reports Medicinal Chem V6 (v. 6). Boston: Academic Press. ISBN 0-12-040506-7.