Keratocan

Keratocan
Identifiers
SymbolsKERA ; CNA2; KTN; SLRR2B
External IDsOMIM: 603288 MGI: 1202398 HomoloGene: 5106 GeneCards: KERA Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1108116545
EnsemblENSG00000139330ENSMUSG00000019932
UniProtO60938O35367
RefSeq (mRNA)NM_007035NM_008438
RefSeq (protein)NP_008966NP_032464
Location (UCSC)Chr 12:
91.44 – 91.45 Mb
Chr 10:
97.61 – 97.61 Mb
PubMed search

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan is a protein that in humans is encoded by the KERA gene.[1][2][3]

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[3]

Mutations of the gene cause cornea plana 2.

References

  1. Tasheva ES, Funderburgh JL, Funderburgh ML, Corpuz LM, Conrad GW (Jan 2000). "Structure and sequence of the gene encoding human keratocan". DNA Seq 10 (1): 67–74. doi:10.3109/10425179909033939. PMID 10565548.
  2. Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H, de la Chapelle A (Jun 2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat Genet 25 (1): 91–5. doi:10.1038/75664. PMID 10802664.
  3. 3.0 3.1 "Entrez Gene: KERA keratocan".

Further reading