Kaposi's sarcoma-associated herpesvirus internal ribosome entry site (IRES)
| Kaposi's sarcoma-associated herpesvirus internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_KSHV | |
| Identifiers | |
| Symbol | IRES_KSHV |
| Rfam | RF00511 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | 0043022 |
| SO | 0000243 |
This family represents the Kaposi's sarcoma-associated herpesvirus (KSHV) internal ribosome entry site (IRES) present in the vCyclin gene. The vCyclin and vFLIP coding sequences are present on a bicistronic transcript and it is thought the IRES may initiate translation of vFLIP from this bicistronic transcript.[1][2]
References
- ↑ Bieleski, L; Talbot SJ (2001). "Kaposi's sarcoma-associated herpesvirus vCyclin open reading frame contains an internal ribosome entry site". J Virol 75 (4): 1864–1869. doi:10.1128/JVI.75.4.1864-1869.2001. PMC 114096. PMID 11160685.
- ↑ Bieleski, L; Hindley C; Talbot SJ (2004). "A polypyrimidine tract facilitates the expression of Kaposi's sarcoma-associated herpesvirus vFLIP through an internal ribosome entry site". J Gen Virol 85 (Pt 3): 615–620. doi:10.1099/vir.0.19733-0. PMID 14993645.