KRT32
| Keratin 32 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KRT32 ; HA2; HKA2; KRTHA2; hHa2 | ||||||||||||
| External IDs | OMIM: 602760 MGI: 1309995 HomoloGene: 68246 GeneCards: KRT32 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3882 | 16670 | |||||||||||
| Ensembl | ENSG00000108759 | ENSMUSG00000046095 | |||||||||||
| UniProt | Q14532 | Q62168 | |||||||||||
| RefSeq (mRNA) | NM_002278 | NM_001159374 | |||||||||||
| RefSeq (protein) | NP_002269 | NP_001152846 | |||||||||||
| Location (UCSC) | Chr 17: 39.62 – 39.62 Mb | Chr 11: 100.08 – 100.09 Mb | |||||||||||
| PubMed search | |||||||||||||
Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.[1][2][3][4]
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[4]
References
- ↑ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444.
- ↑ Rogers MA, Winter H, Langbein L, Krieg T, Schweizer J (Dec 1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J Invest Dermatol 107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID 8823373.
- ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
- ↑ 4.0 4.1 "Entrez Gene: KRT32 keratin 32".
Further reading
- Yu J, Yu DW, Checkla DM et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Adkins JN, Varnum SM, Auberry KJ et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
- Langbein L, Rogers MA, Winter H et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
- Heid HW, Moll I, Franke WW (1988). "Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles". Differentiation 37 (2): 137–57. doi:10.1111/j.1432-0436.1988.tb00805.x. PMID 2456239.
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