KRT31

Keratin 31
Identifiers
SymbolsKRT31 ; HA1; Ha-1; KRTHA1; hHa1
External IDsOMIM: 601077 MGI: 1309993 HomoloGene: 74433 GeneCards: KRT31 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez388116660
EnsemblENSG00000094796ENSMUSG00000048981
UniProtQ15323Q61765
RefSeq (mRNA)NM_002277NM_010659
RefSeq (protein)NP_002268NP_034789
Location (UCSC)Chr 17:
41.39 – 41.4 Mb		Chr 11:
100.05 – 100.05 Mb
PubMed search

Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[3]

References

  1. ↑ Fink P, Rogers MA, Korge B, Winter H, Schweizer J (Dec 1995). "A cDNA encoding the human type I hair keratin hHal". Biochim Biophys Acta 1264 (1): 12–4. doi:10.1016/0167-4781(95)00122-w. PMID 7578244.
  2. ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  3. ↑ 3.0 3.1 "Entrez Gene: KRT31 keratin 31".

Further reading

  • Yu J, Yu DW, Checkla DM et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
  • Dhouailly D, Xu C, Manabe M et al. (1989). "Expression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation". Exp. Cell Res. 181 (1): 141–58. doi:10.1016/0014-4827(89)90189-4. PMID 2465162.
  • Bowden PE, Hainey S, Parker G, Hodgins MB (1995). "Sequence and expression of human hair keratin genes". J. Dermatol. Sci. 7 Suppl: S152–63. doi:10.1016/0923-1811(94)90046-9. PMID 7528047.
  • Winter H, Hofmann I, Langbein L et al. (1998). "A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoform". J. Biol. Chem. 272 (51): 32345–52. doi:10.1074/jbc.272.51.32345. PMID 9405442.
  • Bowden PE, Hainey SD, Parker G et al. (1998). "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle". J. Invest. Dermatol. 110 (2): 158–64. doi:10.1046/j.1523-1747.1998.00097.x. PMID 9457912.
  • Rogers MA, Winter H, Wolf C et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
  • Langbein L, Rogers MA, Winter H et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cribier B, Peltre B, Grosshans E et al. (2004). "On the regulation of hair keratin expression: lessons from studies in pilomatricomas". J. Invest. Dermatol. 122 (5): 1078–83. doi:10.1111/j.0022-202X.2004.22513.x. PMID 15140206.
  • Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.