KPNA3

Karyopherin alpha 3 (importin alpha 4)

Identifiers

KPNA3 ; IPOA4; SRP1; SRP1gamma; SRP4; hSRP1

External IDs

OMIM: 601892 MGI: 1100863 HomoloGene: 20520 GeneCards: KPNA3 Gene

Gene ontology
Molecular function	• protein binding • protein C-terminus binding • nuclear localization sequence binding • protein transporter activity
Cellular component	• nuclear pore • nucleoplasm • cytosol
Biological process	• protein complex assembly • NLS-bearing protein import into nucleus • cytokine-mediated signaling pathway • viral entry into host cell • viral penetration into host nucleus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 13:
50.27 – 50.37 Mb

Chr 14:
61.37 – 61.44 Mb

PubMed search

Importin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene.^[1]^[2]

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60–100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system.^[3]

Interactions

KPNA3 has been shown to interact with KPNB1.^[2]^[4]

References

↑ Takeda S, Fujiwara T, Shimizu F, Kawai A, Shinomiya K, Okuno S, Ozaki K, Katagiri T, Shimada Y, Nagata M, Watanabe T, Takaichi A, Kuga Y, Suzuki M, Hishigaki H, Takahashi E, Shin S, Nakamura Y, Hirai Y (Jun 1997). "Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin, yeast SRP1 and human RCH1". Cytogenet Cell Genet 76 (1–2): 87–93. doi:10.1159/000134521. PMID 9154134.
↑ 2.0 2.1 Nachury MV, Ryder UW, Lamond AI, Weis K (Feb 1998). "Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor". Proc Natl Acad Sci U S A 95 (2): 582–7. doi:10.1073/pnas.95.2.582. PMC 18463. PMID 9435235.
↑ "Entrez Gene: KPNA3 karyopherin alpha 3 (importin alpha 4)".
↑ Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7782–91. ISSN 0270-7306. PMC 84838. PMID 10523667.

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Bukrinsky MI, Haggerty S, Dempsey MP et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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Gallay P, Stitt V, Mundy C et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027–32. PMC 189908. PMID 8551560.
Bukrinskaya AG, Ghorpade A, Heinzinger NK et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. doi:10.1073/pnas.93.1.367. PMC 40239. PMID 8552640.
Sato A, Yoshimoto J, Isaka Y et al. (1996). "Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion". Virology 220 (1): 208–12. doi:10.1006/viro.1996.0302. PMID 8659115.
Popov S, Dubrovsky L, Lee MA et al. (1996). "Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11859–64. doi:10.1073/pnas.93.21.11859. PMC 38149. PMID 8876228.
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Gallay P, Hope T, Chin D, Trono D (1997). "HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9825–30. doi:10.1073/pnas.94.18.9825. PMC 23276. PMID 9275210.

KPNA3

Interactions

References

Further reading