KLK10

Kallikrein-related peptidase 10
Identifiers
SymbolsKLK10 ; NES1; PRSSL1
External IDsOMIM: 602673 MGI: 1916790 HomoloGene: 26428 ChEMBL: 4180 GeneCards: KLK10 Gene
EC number3.4.21.35
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez565569540
EnsemblENSG00000129451ENSMUSG00000030693
UniProtO43240Q99M20
RefSeq (mRNA)NM_001077500NM_133712
RefSeq (protein)NP_001070968NP_598473
Location (UCSC)Chr 19:
51.52 – 51.52 Mb		Chr 7:
43.78 – 43.79 Mb
PubMed search

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.[5]

References

  1. ↑ Liu XL, Wazer DE, Watanabe K, Band V (Sep 1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Res 56 (14): 3371–9. PMID 8764136.
  2. ↑ Polikoff D, Kuo WL, Cochran JF, Wernick M, Kowbel D, Myambo K, Collins CC (Apr 1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet 79 (1-2): 147–8. doi:10.1159/000134705. PMID 9533035.
  3. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
  4. ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
  5. ↑ 5.0 5.1 "Entrez Gene: KLK10 kallikrein-related peptidase 10".

Further reading

  • Diamandis EP, Yousef GM, Luo LY et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis.". Trends Endocrinol. Metab. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891.
  • Zhang Y, Bhat I, Zeng M et al. (2006). "Human kallikrein 10, a predictive marker for breast cancer.". Biol. Chem. 387 (6): 715–21. doi:10.1515/BC.2006.090. PMID 16800732.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Luo L, Herbrick JA, Scherer SW et al. (1998). "Structural characterization and mapping of the normal epithelial cell-specific 1 gene.". Biochem. Biophys. Res. Commun. 247 (3): 580–6. doi:10.1006/bbrc.1998.8793. PMID 9647736.
  • Goyal J, Smith KM, Cowan JM et al. (1998). "The role for NES1 serine protease as a novel tumor suppressor.". Cancer Res. 58 (21): 4782–6. PMID 9809976.
  • Harvey TJ, Hooper JD, Myers SA et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.
  • Gan L, Lee I, Smith R et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
  • Dhar S, Bhargava R, Yunes M et al. (2002). "Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer.". Clin. Cancer Res. 7 (11): 3393–8. PMID 11705853.
  • Bharaj BB, Luo LY, Jung K et al. (2002). "Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.". Prostate 51 (1): 35–41. doi:10.1002/pros.10076. PMID 11920956.
  • Luo LY, Diamandis EP, Look MP et al. (2002). "Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.". Br. J. Cancer 86 (11): 1790–6. doi:10.1038/sj.bjc.6600323. PMC 2375391. PMID 12087468.
  • Petraki CD, Karavana VN, Luo LY, Diamandis EP (2002). "Human kallikrein 10 expression in normal tissues by immunohistochemistry.". J. Histochem. Cytochem. 50 (9): 1247–61. doi:10.1177/002215540205000912. PMID 12185203.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Petraki CD, Gregorakis AK, Papanastasiou PA et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.". Prostate Cancer Prostatic Dis. 6 (3): 223–7. doi:10.1038/sj.pcan.4500674. PMID 12970725.
  • Sauter ER, Lininger J, Magklara A et al. (2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk.". Int. J. Cancer 108 (4): 588–91. doi:10.1002/ijc.11607. PMID 14696124.
  • Diamandis EP, Scorilas A, Kishi T et al. (2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.". Clin. Biochem. 37 (3): 230–7. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.
  • Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links