KLF5
Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[1][2]
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[2]
Interactions
KLF5 has been shown to interact with Protein SET.[3]
See also
References
- ↑ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (May 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Res 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902.
- ↑ 2.0 2.1 "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
- ↑ Miyamoto, Saku; Suzuki Toru, Muto Shinsuke, Aizawa Kenichi, Kimura Akatsuki, Mizuno Yoshiko, Nagino Tomoko, Imai Yasushi, Adachi Naruhiko, Horikoshi Masami, Nagai Ryozo (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Mol. Cell. Biol. (United States) 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. ISSN 0270-7306. PMC 262669. PMID 14612398.
Further reading
- Ghaleb AM; Nandan MO; Chanchevalap S et al. (2005). "Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation". Cell Res. 15 (2): 92–6. doi:10.1038/sj.cr.7290271. PMC 1317089. PMID 15740636.
- Nagai R; Suzuki T; Aizawa K et al. (2005). "Significance of the transcription factor KLF5 in cardiovascular remodeling". J. Thromb. Haemost. 3 (8): 1569–76. doi:10.1111/j.1538-7836.2005.01366.x. PMID 16102021.
- McConnell BB, Ghaleb AM, Nandan MO, Yang VW (2007). "The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology". Bioessays 29 (6): 549–57. doi:10.1002/bies.20581. PMC 2211634. PMID 17508399.
- Kojima S; Kobayashi A; Gotoh O et al. (1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". J. Biochem. 121 (2): 389–96. doi:10.1093/oxfordjournals.jbchem.a021600. PMID 9089417.
- Conkright MD, Wani MA, Anderson KP, Lingrel JB (1999). "A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells". Nucleic Acids Res. 27 (5): 1263–70. doi:10.1093/nar/27.5.1263. PMC 148310. PMID 9973612.
- Shi H; Zhang Z; Wang X et al. (2000). "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter". Nucleic Acids Res. 27 (24): 4807–15. doi:10.1093/nar/27.24.4807. PMC 148782. PMID 10572182.
- Hoshino Y; Kurabayashi M; Kanda T et al. (2000). "Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis". Circulation 102 (20): 2528–34. doi:10.1161/01.cir.102.20.2528. PMID 11076828.
- Sun R, Chen X, Yang VW (2001). "Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation". J. Biol. Chem. 276 (10): 6897–900. doi:10.1074/jbc.C000870200. PMC 2268089. PMID 11152667.
- Dang DT; Zhao W; Mahatan CS et al. (2002). "Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene". Nucleic Acids Res. 30 (13): 2736–41. doi:10.1093/nar/gkf400. PMC 117055. PMID 12087155.
- Shindo T; Manabe I; Fukushima Y et al. (2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nat. Med. 8 (8): 856–63. doi:10.1038/nm738. PMID 12101409.
- Sur I, Undén AB, Toftgård R (2003). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". Eur. J. Cell Biol. 81 (6): 323–34. doi:10.1078/0171-9335-00257. PMID 12113473.
- Chen C, Bhalala HV, Qiao H, Dong JT (2002). "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer". Oncogene 21 (43): 6567–72. doi:10.1038/sj.onc.1205817. PMID 12242654.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yang XO, Doty RT, Hicks JS, Willerford DM (2003). "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs". Blood 101 (11): 4492–9. doi:10.1182/blood-2002-08-2579. PMID 12576331.
- Chen C, Bhalala HV, Vessella RL, Dong JT (2003). "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer". Prostate 55 (2): 81–8. doi:10.1002/pros.10205. PMID 12661032.
- Zhang Z, Teng CT (2003). "Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function". Nucleic Acids Res. 31 (8): 2196–208. doi:10.1093/nar/gkg310. PMC 153738. PMID 12682370.
- Ohnishi S; Ohnami S; Laub F et al. (2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochem. Biophys. Res. Commun. 308 (2): 251–6. doi:10.1016/S0006-291X(03)01356-1. PMID 12901861.
- Aizawa K; Suzuki T; Kada N et al. (2004). "Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB". J. Biol. Chem. 279 (1): 70–6. doi:10.1074/jbc.M306621200. PMID 14573617.
- Sato T; Kanda T; Iida T et al. (2004). "Immunohistochemical study of surgically excised choroidal neovascular membranes". J. Int. Med. Res. 31 (5): 402–6. doi:10.1177/147323000303100507. PMID 14587307.
External links
- KLF5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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