KLC3

Kinesin light chain 3

Identifiers

KLC3 ; KLC2; KLC2L; KLCt; KNS2B

External IDs

OMIM: 601334 MGI: 1277971 HomoloGene: 14899 GeneCards: KLC3 Gene

Gene ontology
Molecular function	• microtubule motor activity • microtubule binding • kinesin binding
Cellular component	• cytoplasm • kinesin complex • microtubule • motile cilium • ciliary rootlet • neuron projection
Biological process	• axon cargo transport • metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000104892

ENSMUSG00000040714

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
45.84 – 45.85 Mb

Chr 7:
19.39 – 19.4 Mb

PubMed search

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.^[1]

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.^[1]

Interactions

KLC3 has been shown to interact with YWHAH.^[2]

References

↑ 1.0 1.1 "Entrez Gene: KLC3 kinesin light chain 3".
↑ Ichimura, Tohru; Wakamiya-Tsuruta Akiko, Itagaki Chiharu, Taoka Masato, Hayano Toshiya, Natsume Tohru, Isobe Toshiaki (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry (United States) 41 (17): 5566–72. doi:10.1021/bi015946f. ISSN 0006-2960. PMID 11969417.

Further reading

Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Y, Oko R, van der Hoorn FA (2004). "Rat kinesin light chain 3 associates with spermatid mitochondria". Dev. Biol. 275 (1): 23–33. doi:10.1016/j.ydbio.2004.07.014. PMC 3138780. PMID 15464570.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bhullar B, Zhang Y, Junco A et al. (2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". J. Biol. Chem. 278 (18): 16159–68. doi:10.1074/jbc.M213126200. PMC 3178653. PMID 12594206.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang J, Liu X, Yue G et al. (2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". J. Cell Biol. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070. PMID 12427867.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C et al. (2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.
Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biol. Reprod. 64 (5): 1320–30. doi:10.1095/biolreprod64.5.1320. PMC 3161965. PMID 11319135.
Rahman A, Kamal A, Roberts EA, Goldstein LS (1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.
Rahman A, Friedman DS, Goldstein LS (1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122.
Lamerdin JE, Stilwagen SA, Ramirez MH et al. (1996). "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes". Genomics 34 (3): 399–409. doi:10.1006/geno.1996.0303. PMID 8786141.