KIFC3

Kinesin family member C3

PDB rendering based on 2h58.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2H58

Identifiers

KIFC3 ; DKFZp686D23201; FLJ34694

External IDs

OMIM: 604535 MGI: 109202 HomoloGene: 124421 ChEMBL: 1075119 GeneCards: KIFC3 Gene

Gene ontology
Molecular function	• microtubule motor activity • ATP binding • microtubule binding
Cellular component	• Golgi apparatus • centrosome • kinesin complex • microtubule • zonula adherens • cytoplasmic vesicle membrane • extracellular vesicular exosome
Biological process	• microtubule-based movement • Golgi organization • visual perception • metabolic process • zonula adherens maintenance • epithelial cell-cell adhesion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000140859

ENSMUSG00000031788

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
57.79 – 57.9 Mb

Chr 8:
95.1 – 95.14 Mb

PubMed search

Kinesin-like protein KIFC3 is a protein that in humans is encoded by the KIFC3 gene.^[1]^[2]

References

↑ Hoang EH, Whitehead JL, Dose AC, Burnside B (Dec 1998). "Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome". Genomics 52 (2): 219–22. doi:10.1006/geno.1998.5431. PMID 9782090.
↑ "Entrez Gene: KIFC3 kinesin family member C3".

Further reading

Diu A, Moebius U, Ferradini L et al. (1993). "Limited T-cell receptor diversity in liver-infiltrating lymphocytes from patients with primary biliary cirrhosis.". J. Autoimmun. 6 (5): 611–9. doi:10.1006/jaut.1993.1050. PMID 8240664.
Hoang E, Bost-Usinger L, Burnside B (1999). "Characterization of a novel C-kinesin (KIFC3) abundantly expressed in vertebrate retina and RPE.". Exp. Eye Res. 69 (1): 57–68. doi:10.1006/exer.1999.0671. PMID 10375449.
Noda Y, Okada Y, Saito N et al. (2001). "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes.". J. Cell Biol. 155 (1): 77–88. doi:10.1083/jcb.200108042. PMC 2150803. PMID 11581287.
Xu Y, Takeda S, Nakata T et al. (2002). "Role of KIFC3 motor protein in Golgi positioning and integration.". J. Cell Biol. 158 (2): 293–303. doi:10.1083/jcb.200202058. PMC 2173137. PMID 12135985.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes.". BMC Genomics 8: 42. doi:10.1186/1471-2164-8-42. PMC 1802077. PMID 17286855.

PDB gallery

2h58: Crystal structure of the KIFC3 motor domain in complex with ADP